Follicular Lymphoma Clinical Trial
Official title:
A Phase I/II Trial of VR-CHOP for Patients With Untreated Follicular Lymphoma and Other Low Grade B-Cell Lymphomas
This is an open-label (doctors and patients know which drug will be given), single center, phase 1/2 clinical trial. The primary objective is to determine whether VR-CHOP provides benefit to patients with previously untreated indolent non-Hodgkin's lymphomas (NHL).
This study will assess whether adding bortezomib (Velcade) to R-CHOP (in a new combination
called VR-CHOP) can further improve outcomes in patients with indolent NHL who have not
previously received treatment.
Patients who are eligible to take part in the study will receive VR-CHOP at the doses of
Velcade and vincristine established in phase 1. Patients will receive VR-CHOP for up to 8
cycles of treatment (each of 21 days duration). During treatment, patients will be assessed
for their response to therapy and for possible side effects. All patients will go on to
receive maintenance therapy after completion of their initial treatment as designed by the
protocol.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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