Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT02245477 |
Other study ID # |
Beni-Suef 5 |
Secondary ID |
|
Status |
Recruiting |
Phase |
|
First received |
|
Last updated |
|
Start date |
September 2014 |
Est. completion date |
June 2021 |
Study information
Verified date |
January 2021 |
Source |
Beni-Suef University |
Contact |
Nesreen A Shehata, MD |
Phone |
00201227866337 |
Email |
nesoomar[@]yahoo.com |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
In this study we explore To explore the role of maternal serum vascular endothelial growth
factor (VEGF) in pregnancies complicated by foetal growth restriction.
Description:
Small-for-gestational age (SGA) is defined as an estimated foetal weight (EFW) or abdominal
circumference (AC) less than the 10th centileand severe SGA as an EFW or AC less than the 3rd
centile. Foetal Growth Restriction refers to failure of the foetus to achieve its
predetermined growth potential for various reasons.Foetus with foetal growth restriction
(FGR) greatly contributes to perinatal mortality and short- and long-term morbidity. There is
a 3-10 fold increase in perinatal mortality in pregnancies complicated by this FGR .The
incidence of FGR in newborns ranges between 3 and 7% of the total population .FGR is thought
to stem from placental hypoxia-induced vasoconstriction of the fetoplacental vessels, leading
to placental hypoperfusion and thus fetal undernutrition. However, the effects of hypoxia on
the fetoplacental vessels have been surprisingly little studied.Vascular endothelial growth
factor (VEGF) is one of the factors that take part in placental angiogenesis. It is highly
expressed during embryonic and foetal development..Angiogenesis involves the branching of new
microvessles from pre-existing larger blood vessels.Angiogenesis plays a role in the
development of the villous vasculature and the formation of terminal villi in human placenta.
IUGR occurs as a result of the failure of elongation, branching and dilatation of the
capillary loops and of terminal villous formation.