Fluid Therapy Clinical Trial
Official title:
Restrictive Versus Conservative Fluid Therapy in Colorectal Surgery: Hemodynamics and Kidney Function Outcomes
NCT number | NCT03070080 |
Other study ID # | 23140000178 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | January 1, 2017 |
Est. completion date | May 7, 2018 |
Verified date | March 2017 |
Source | Assiut University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Fluid administration during and after surgery is an essential part of postoperative care to maintain the patients' fluid and biochemical balance. Abdominal surgical procedures are associated with dehydration from preoperative fasting, bowel preparation, and intra- and postoperative fluid and electrolyte loss. So, perioperative fluid management has been a topic of much debate over years and has intensified especially over the past several years.
Status | Completed |
Enrollment | 60 |
Est. completion date | May 7, 2018 |
Est. primary completion date | May 1, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: 1. Adult patients scheduled for colorectal surgery 2. American Society of Anesthesiologists grade I-II. Exclusion criteria: 1. patient refusal. 2. psychiatric disorders. 3. pregnancy and lactation. 4. preexisting neurological dysfunction ( history of cerebrovascular stroke CVS) 5. Allergy to any protocol medication. 6. metastatic cancer. 7. Inflammatory bowel disease. 8. Coronary artery disease with impaired cardiac function. 9. Diabetes mellitus. 10. Renal insufficiency (serum creatinine level more than 180 µmol/l). 11. unexpected intraoperative findings (small bowel obstruction, inoperable). 12. accidental massive intraoperative haemorrhage. |
Country | Name | City | State |
---|---|---|---|
Egypt | Assiut Iniversity hospitals | Assiut |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Neutrophil Gelatinase-associated Lipocalin (NGAL) | NGAL is a renal biomarker for acute kidney injury | 24 hours postoperative | |
Secondary | mean arterial blood pressure | non invasive measurement of mean arterial blood pressure | intraoperative | |
Secondary | heart rate | measurement of heart rate from pulse oximetry | intraoperative | |
Secondary | pleth-variability index | derived from respiratory variations in peripheral perfusion index. | intraoperative | |
Secondary | incidence of bradycardia | bradycardia defined as heart rate less than 50 beat per minute | intraoperative | |
Secondary | incidence of hypotension | hypotension defined as systolic blood pressure less than 40% of baseline value | intraoperative |
Status | Clinical Trial | Phase | |
---|---|---|---|
Not yet recruiting |
NCT06351475 -
Efficacy of Intraoperative Use of 20% Albumin Combined With Ringer Lactate Versus Ringer Lactate During Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy
|
N/A | |
Not yet recruiting |
NCT04982016 -
Effects of Fluid Therapy on Microcirculatory Reactivity
|
N/A | |
Completed |
NCT03215797 -
Phenylephrine or Norepinephrine for a Better Hemodynamic Stability
|
Phase 3 | |
Completed |
NCT04536324 -
The Absorption Rate of Subcutaneous Infused Fluid
|
||
Completed |
NCT02977390 -
Passive Leg Raise Induced Stroke Volume Changes in Elderly Prior to Elective Surgery Measured by LiDCOplusTM
|
N/A | |
Recruiting |
NCT01415284 -
ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia
|
Phase 4 | |
Completed |
NCT03245372 -
Goal Directed Therapy Versus Standard Care in Lung Resection Surgery (GDT-thorax Study).
|
N/A | |
Recruiting |
NCT05606536 -
The Impact of Intra-operative Fluid Infusion Rate on Microcirculation
|
N/A | |
Terminated |
NCT03553394 -
Effects of Restrictive Fluid Strategy on Postoperative Oliguric Pancreatic Surgery Patients
|
N/A | |
Recruiting |
NCT05153837 -
Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers
|
N/A | |
Completed |
NCT03323580 -
Effects of Intraoperative GDFT on the Postoperative Brain Edema
|
N/A | |
Completed |
NCT03394833 -
Hemodynamic Stability During Induction of Anaesthesia
|
N/A | |
Completed |
NCT03280953 -
Assessing Fluid Responsiveness With PWTT
|
||
Not yet recruiting |
NCT06256120 -
Effect of Fluid Regimen on Acute Kidney Injury
|
N/A | |
Recruiting |
NCT03178578 -
A Prospective Observational Study of the Expectations and Physiological Effects of Fluid Bolus Therapy
|
||
Enrolling by invitation |
NCT04388995 -
SVV and PPV Predict Fluid Responsiveness in Mechanically Ventilated Elderly Patients Under General Anesthesia
|
N/A | |
Not yet recruiting |
NCT06396884 -
Hemodynamic Optimization During Spinal Anesthesia in the Elderly
|
||
Recruiting |
NCT05369559 -
Mini Bolus for Fluid Challenge Responsiveness in the Emergency Department
|
Early Phase 1 | |
Recruiting |
NCT05054452 -
Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocardiography
|
N/A | |
Completed |
NCT03060408 -
Comparison of Fluid Requirements in Pancreatectomy: Laparotomy vs. Laparoscopy
|
N/A |