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Fluid Therapy clinical trials

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NCT ID: NCT05961137 Completed - Sepsis Clinical Trials

Orange Park Out-of-Hospital Quality Improvement Study for Improving CMS Sepsis Core Measures

Start date: April 1, 2021
Phase: N/A
Study type: Interventional

The goal of this quality improvement study is to measure the impact of incorporation of a manual rapid fluid infuser (RFI) for intravenous crystalloid infusion in patients with suspected sepsis in the prehospital interval. The main question[s] it aims to answer are: - Does the intervention affect the timeliness of fluid administration? - Does the intervention affect CMS sepsis bundle care measure compliance? - Does the intervention affect processes and outcomes of care? - Are there any adverse effects? Researchers will compare this intervention to use of more conventional gravity or pressure-infusion bag crystalloid infusion.

NCT ID: NCT05487222 Completed - Fluid Therapy Clinical Trials

Goal Directed and Liberal Fluid Therapy

Start date: January 10, 2020
Phase:
Study type: Observational

The aim is to compare intraoperative goal directed fluid therapy (GDFT) versus liberal fluid therapy in patients undergoing elective colorectal surgery by using noninvasive electrical cardiometry. This study hypothesized that GDFT is better than liberal fluid therapy to provide sufficient intra-vascular fluid volume for adequate perfusion without impairing glycolcalyx function with fluid overload

NCT ID: NCT04781361 Completed - Fluid Therapy Clinical Trials

Comparison of the Isotonic and Hypotonic Intravenous Maintenance Fluids In Term Newborns: Neofluid Study

NEOFLUID
Start date: December 30, 2020
Phase:
Study type: Observational

Considering the physiological changes in fluid and electrolyte balance and providing proper support are one of the important aspects of neonatal intensive care. Maintenance intravenous fluids are designed to maintain homeostasis when a patient is unable to uptake required water, electrolytes, and energy. Hypotonic fluids are still the most commonly prescribed IV fluids for pediatric hospitalized patients. However, previous studies, including children older than one month of age revealed that traditionally used hypotonic fluids may lead to hyponatremia. Because of the absence of evidence-based data, there is currently no clear consensus on the optimal composition of maintenance intravenous fluid therapy in newborns, leading to wide practice variation. The National Clinical Guideline Center (NICE) 2015 recommends the use of isotonic fluids in term newborn infants and some newborn centers has begun to use isotonic fluids since guidelines recommendations. Since the publication of the NICE guideline, no studies have addressed this topic. In this prospective, observational , multicentric study, conventional hypotonic fluids containing sodium chloride (NaCl) < 130 mmol/L compared with isotonic fluids (containing NaCl between 131-154 mmol/L) in terms of the risk of hyponatremia, hypernatremia, plasma sodium (pNa) level change, treatment morbidities, hospitalization duration and mortality.

NCT ID: NCT04536324 Completed - Aged Clinical Trials

The Absorption Rate of Subcutaneous Infused Fluid

ABSU
Start date: September 1, 2020
Phase:
Study type: Observational

The purpose of the study is to examine the rate of absorption of subcutaneous infused fluid in older adults when acutely ill compared to when they are not acutely ill.

NCT ID: NCT04512950 Completed - Fluid Therapy Clinical Trials

Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients

FLUID
Start date: August 15, 2016
Phase: Phase 4
Study type: Interventional

The aim of the FLUID Trial is to conduct a pragmatic, multi-centre, open label randomized cluster cross-over trial (RCT) to determine whether fluid administration with 0.9% saline as compared to Ringer's lactate decreases death or re-admission to hospital with 90 days of the index admission.

NCT ID: NCT03972475 Completed - Critical Care Clinical Trials

The Effect of Maintenance Fluids on Overall Fluid Balance in ICU Patients

Start date: January 1, 2018
Phase:
Study type: Observational [Patient Registry]

The amount of fluids characterized as non-resuscitation fluids given to ICU patients are likely to be high and will probably have a substantial impact on the total amount of fluid administered to ICU patients daily. It will most likely also influence on the total fluid balance and the negative outcome of fluid overload. The aim of our study is to investigate the amount of fluid given as maintenance fluids in the ICU and the impact of this fluid on total fluid balance.

NCT ID: NCT03842722 Completed - Sepsis Clinical Trials

Insufficient Oxygenation in Septic Patients

INOX-SEPSIS
Start date: February 13, 2019
Phase:
Study type: Observational

This study will describe the change of mitochondrial oxygen tension (mitoPO2) compared to traditional parameters of oxygenation and oxygen balance in the first 24 hours of septic patients admitted to the intensive care unit of an academic hospital. The mitoPO2 will be measured on prespecified measurement moments in the ICU. With each measurement moment, arterial and central venous blood gasses will be taken too.

NCT ID: NCT03394833 Completed - Clinical trials for Hemodynamic Instability

Hemodynamic Stability During Induction of Anaesthesia

Start date: November 20, 2017
Phase: N/A
Study type: Interventional

The study aim is to investigate if preoperative volume bolus based on lean body weight could preserve mean arterial pressure during target controlled infusion of anaesthesia (TCI) or rapid sequence induction of anaesthesia (RSI) in non-cardiac, non-morbidly obese surgery.

NCT ID: NCT03323580 Completed - Brain Tumor Clinical Trials

Effects of Intraoperative GDFT on the Postoperative Brain Edema

Start date: November 26, 2018
Phase: N/A
Study type: Interventional

Whether a fluid protocol aiming for protecting vital organ perfusion or fluid restriction is favorable to post-craniotomy outcomes such as brain edema remains uncertain. To our knowledge, there has been no extensive and quantitative analysis of brain edema following SVV-based GDFT in neurosurgical patients with malignant supratentorial glioma. So the study aims to observe the effect of the stroke volume variation-based GDFT on the postoperative brain edema and decrease the incidence of postoperative complications in neurosurgical patients with malignant supratentorial gliomas.

NCT ID: NCT03280953 Completed - Fluid Therapy Clinical Trials

Assessing Fluid Responsiveness With PWTT

Start date: May 31, 2016
Phase:
Study type: Observational

Pulse wave Transit time (PWTT) is a parameter calculated from ECG and pulseoximeter. It is supposed to help assessing the preload Status and guide intraoperative fluid therapy. This Project aims to validate the benefit of PWTT assessment in an observational clinical fluid study. In case of hypovolemia, patients will receive a fluid Bolus and hemodynamic data from clinical Standard Monitoring, esophageal doppler and PWTT will be recorded before and after the fluid Bolus. Receiver operating characteristic (ROC) curve will be used to determine the validity of PWTT as indicator for fluid responsiveness and its cut off value.