Fibromyalgia Clinical Trial
— QEEGFPOfficial title:
Quantitative and Qualitative EEG From Fibromyalgia Patients for the Identification of Abnormal Patterns on Closed Eyes EEG
Verified date | July 2023 |
Source | Spanish Foundation for Neurometrics Development |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Fibromyalgia is a relatively young condition recently recognized by the WHO as a separated clinical entity. Part of the medical comunity thinks of it as a mixed condition between depresion and rheumatic pain, however, functional data provided by sophisticated imaging techniques points at a diminished brain activity in several brain regions. The present study aims to characterize those findings by means of QEEG in order to establish the electroencephalographic characteristics of fibromyalgia patients.
Status | Completed |
Enrollment | 150 |
Est. completion date | March 12, 2023 |
Est. primary completion date | January 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 70 Years |
Eligibility | Inclusion Criteria: - Men and women between 20 and 70 years old, diagnosed with fibromyalgia and a control group matched by age and gender Exclusion Criteria: - Any other concomitant neurologic disease or impairment |
Country | Name | City | State |
---|---|---|---|
Spain | Universidad de Murcia | Murcia |
Lead Sponsor | Collaborator |
---|---|
Spanish Foundation for Neurometrics Development | Universidad de Murcia |
Spain,
Branco J, Atalaia A, Paiva T. Sleep cycles and alpha-delta sleep in fibromyalgia syndrome. J Rheumatol. 1994 Jun;21(6):1113-7. — View Citation
Drewes AM. Pain and sleep disturbances with special reference to fibromyalgia and rheumatoid arthritis. Rheumatology (Oxford). 1999 Nov;38(11):1035-8. doi: 10.1093/rheumatology/38.11.1035. No abstract available. — View Citation
Flodin P, Martinsen S, Lofgren M, Bileviciute-Ljungar I, Kosek E, Fransson P. Fibromyalgia is associated with decreased connectivity between pain- and sensorimotor brain areas. Brain Connect. 2014 Oct;4(8):587-94. doi: 10.1089/brain.2014.0274. Epub 2014 A — View Citation
Napadow V, Harris RE. What has functional connectivity and chemical neuroimaging in fibromyalgia taught us about the mechanisms and management of 'centralized' pain? Arthritis Res Ther. 2014;16(5):425. doi: 10.1186/s13075-014-0425-0. — View Citation
Rains JC, Penzien DB. Sleep and chronic pain: challenges to the alpha-EEG sleep pattern as a pain specific sleep anomaly. J Psychosom Res. 2003 Jan;54(1):77-83. doi: 10.1016/s0022-3999(02)00545-7. — View Citation
Schmidt-Wilcke T, Ichesco E, Hampson JP, Kairys A, Peltier S, Harte S, Clauw DJ, Harris RE. Resting state connectivity correlates with drug and placebo response in fibromyalgia patients. Neuroimage Clin. 2014 Sep 16;6:252-61. doi: 10.1016/j.nicl.2014.09.0 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Differences between groups in Fast Fourier Transformation | Changes in Power in EEG over different electrodes | Up to one year | |
Primary | Topographic distribution of the frequency bands | Brain areas with a characteristic pattern | Up to one year | |
Primary | Dominant EEG frequency localization | To document the dominant frequency in the resting EEG for all subjects | Up to one year | |
Primary | Abnormal EEG-graphoelements description | To identify the abnormal EEG-graphoelements found in fibromyalgia patients | Up to one year | |
Primary | Functional conectivity | To identify the different brain connections between fibromyalgia patients | Up to one year |
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