Fibromyalgia Clinical Trial
Official title:
Mechanisms of Acupuncture Analgesia
This study will determine the effectiveness of acupuncture versus a placebo in altering brain activity and relieving pain due to fibromyalgia.
Fibromyalgia is one of the most common rheumatic diseases, second only to osteoarthritis. It
causes chronic muscle pain and fatigue. Acupuncture functions by targeting specific nerve
pathways to different organs or parts of the body. Research has shown that acupuncture is
effective in decreasing or eliminating people's sensitivity to pain in targeted regions.
However, some believe that the reduction in pain is due to a placebo response rather than
acupuncture itself. This study will use two brain-imaging techniques to determine the brain
response to acupuncture versus a simulation of acupuncture, thereby assessing whether
acupuncture is actually effective in relieving pain.
Participants in this single-blind study will be randomly assigned to receive either
acupuncture or a placebo treatment. The placebo will consist of a simulation of acupuncture.
Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) will be
used to assess activity of brain mu-opioid receptors. These receptors are involved in the
body's ability to perceive pain. All participants will be scanned twice using the fMRI
scanner, once before any treatment sessions and once at the conclusion of all treatment
sessions. Both fMRI sessions will involve applying pressure to the thumb to elicit a
response in the brain in order to assess the corresponding fMRI blood oxygen level dependent
(BOLD) signal and whether this activation changes after treatment intervention. Participants
will then receive nine treatments of acupuncture or placebo outside the scanner over a
4-week period. The PET portion of this study is optional, and, if you elect to participate,
your first treatment session will be performed in the PET scanner. After this first session,
participants will have seven additional treatment sessions outside of the scanner over a
4-week period. The last session will be performed in the PET scanner to assess changes in
mu-opioid receptor activity that may have occurred over the 4 weeks. A baseline visit to
determine eligibility and a close-out visit at week 8 are also part of the participation
schedule. It is very important that participants live within driving distance of Ann Arbor,
MI due to the significant number of visits to our Center.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
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