Clinical Trials Logo

Clinical Trial Summary

Despite technical advances in Medically Assisted Reproduction (AMP), the success of fertility treatments is sometimes limited by embryo implantation failure. The coordinated development of the embryo and the uterine endometrium requires close communication between the maternal tissue and the embryo. In in vitro fertilization (IVF), embryo transfer generally takes place between the 2nd (D2) and the 6th (D6) day following oocyte fertilization. Recent studies have shown the advantages of sequential transfer (transfer of an embryo on D2/D3 followed by the transfer of another embryo on D5/D6), with higher implantation and clinical pregnancy rate, fewer miscarriages, more live births, and yet no increase in multiple pregnancies. However, the American Society for Reproductive Medicine recommendations continue to prioritize the transfer of a single embryo for all patients aged under 38. To improve pregnancy rates for patients having a single embryo transferred, the study investigators wish to carry out on "blank" transfer, based on the principle of sequential transfer. The study investigators hypothesize that a culture medium, placed in the uterus before the time of embryo transfer, will modify immune tolerance. The study will test whether transferring the same culture medium in an equivalent quantity as during the real transfer into the uterus 2/3 days before the embryo transfer will improve tolerance to this foreign medium and, therefore, embryo implantation. The aim of this study is thus to evaluate the impact of a "blank" transfer with culture medium alone, on the results of frozen embryo transfers (FET) from IVF.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06177613
Study type Interventional
Source Centre Hospitalier Universitaire de Nimes
Contact Nathalie Rougier
Phone 04.66.68.32.24
Email nathalie.rougier@chu-nimes.fr
Status Recruiting
Phase N/A
Start date February 9, 2024
Completion date February 2027

See also
  Status Clinical Trial Phase
Completed NCT04213781 - Interest of Audiovisual Distraction in the Management of Anxiety and Pain During Oocyte Retrieval N/A
Completed NCT00608010 - Day 3 Embryo Cryopreservation: Metabolic and Viability Analysis N/A
Completed NCT03527823 - The Comparison of Granulosa Cell Apoptosis Rates With or Without Luteinizing Hormone Administration in Poor Responders.
Not yet recruiting NCT02971280 - Influence of Heavy Metals Exposure on in Vitro Fertilization (IVF) Outcome N/A
Terminated NCT02990949 - The Impact of the Timing of Trigger on IVF Success N/A
Completed NCT00920361 - Designated Drug Use Investigation 1 of Follistim Injection (Study P06130)(COMPLETED)
Recruiting NCT06134609 - Does Sexual Intercourse Affect the Outcomes of Frozen-thawed Embryo Transfer? N/A
Completed NCT03238833 - Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation N/A
Withdrawn NCT03062098 - Optimizing the Technique of Embryo Transfer in IVF Using Better Imaging Guidance N/A
Recruiting NCT06410417 - Ejaculation Abstinence Time and Assisted Reproductive Technology Outcomes N/A
Not yet recruiting NCT06385444 - IVF Failure and Pregnancy Loss on Couples' Psychological Stress
Recruiting NCT03700255 - Efficacy of a Simulator Based (PickUpSimTM) Residents' Training Program for Oocyte Retrievals N/A
Recruiting NCT04935658 - Oocyte Retrieval and Virtual Reality (REVPO) N/A
Recruiting NCT03713723 - Cardiac Output Monitoring in IVF Patients
Completed NCT03733912 - Plasticizers and in Vitro Fertilization Outcomes
Not yet recruiting NCT06433518 - BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)
Completed NCT02323347 - Cut-Off Progesterone Values Deleterious for In Vitro Fertilization and Fresh Embryo Transfer N/A
Completed NCT00750451 - Low Molecular Weight Heparin in Recurrent Implantation Failure N/A
Recruiting NCT04124913 - Oral Dydrogesterone vs. Micronized Vaginal Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer Cycles Phase 4
Completed NCT04755270 - Virtual Reality-Supported Hypnofertility N/A