Fertility Clinical Trial
Official title:
Fertility Study of Women Who Received Organ Transplantation
In terms of immunity, pregnancy can be considered a semi-allogeneic transplant. There are
several immunological mechanisms for implantation and maintenance of pregnancy by induction
of tolerance without induction of immunosuppression.
This study wants to evaluate the impact of immunodepression on women's fertility by studying
the fertility of transplanted cardiac, renal, hepatic and pulmonary women.
A study of HIV-positive immunocompromised patients in medically assisted procreation,
published in January 2016, found lower rates of implantation, clinical pregnancy, and newborn
babies in these patients compared to HIV-negative patients.
Studying the fertility of transplanted immunocompromised women would provide adequate
information on fertility and pregnancy possibilities for these patients, study their
fertility on a larger scale and finally better understand the role of immunodepression in
fertility.
Pregnancy is considered an allogeneic semi-graft, one can question the fertility of these
patients under long-term immunosuppressive treatment. In particular, is there an impact on
embryo implantation and on the development of pregnancy? To try to answer this problematic,
we propose a retrospective non-interventional study to evaluate the birth rate after
spontaneous or induced pregnancy in women who have tried to procreate after
transplantation.The data will be collected using questionnaires submitted to the women
present in the list of patients transplanted from the Organ Transplant Unit (OTU) of Toulouse
University Hospital who have agreed to participate. This will make it possible to
retrospectively study fertility data in these patients and to carry out, with the necessary
hindsight, statistics on pregnancy rates.
The primary outcome measure: birth rate after spontaneous or induced pregnancy in liver,
heart, lung or kidney transplant patients who have attempted to procreate post-transplant is
a good primary endpoint because it is a unique clinical criterion. relevant to the purpose of
the study, specific and objective.
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