Taste Acuity and Caloric Intake After Acute Morphine Administration

Feeding Behavior Clinical Trial

Official title:

Taste Acuity and Caloric Intake After Acute Morphine Administration

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01763697
• Other study ID #: NA_00046407
• Secondary ID: K24DA023186-06
• Status: Completed
• Phase: N/A
• First received: January 7, 2013
• Last updated: May 28, 2014
• Start date: March 2013
• Est. completion date: May 2014

Study information

• Verified date: May 2014
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 36
• Est. completion date: May 2014
• Est. primary completion date: May 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Healthy adult male and female volunteers

• Ages of 18 to 65

Exclusion Criteria:

• History of drug dependence (including opioid use disorders)

• History of taste dysfunction

• Significant medical or Axis I psychiatric disorder

• Any trauma or surgical procedures to the head or neck region

• Medication or illicit drug more than 4 out of the last 30 days.

• Pregnancy

• Abnormal electrocardiogram findings

• Negative rating of greater than 40% of the foods available for consumption

Study Design

Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Feeding Behavior
• Taste Salty
• Taste Sweet

Intervention

Behavioral:
• taste acuity assessment
Quantitative measurement of for tasting detection and recognition thresholds, magnitude of perception and hedonic response.
• Recorded meal

Locations

Country	Name	City	State
United States	Johns Hopkins Bayview Medical Center	Baltimore	Maryland

Sponsors (2)

Lead Sponsor	Collaborator
Johns Hopkins University	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Taste	The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response.	3 hours after dose administration	No
Secondary	Calories	The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration.	6 hours after dose administration	No