Fatty Liver Clinical Trial
Official title:
Double Blind, Randomized, Placebo Controlled Trial With Metformin in Non-Alcoholic Fatty Liver Disease (NAFLD)
The study evaluates the use of the antidiabetic medicine metformin in nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is a prevalent disorder associated with insulin
resistance. Metformin is a drug that has been used for several decades in the treatment of
diabetes mellitus. Metformin is known to improve insulin sensitivity. Some authors have
reported beneficial effects of metformin in NAFLD, others have not been able to reproduce
these findings. Only a few randomized controlled studies have been published so far, and
there is still need for controlled trials with sufficient power to assess the efficacy of
metformin in this condition.
The aim of this study is to see whether treatment with metformin for 26 weeks results in
reduction of liver steatosis (primary endpoint) and reduction in grade of inflammation in
those with non-alcoholic steatohepatitis (NASH) (secondary endpoint).
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
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