Fasting Clinical Trial - A New Model of Acute Febrile Disease

Status Completed

Clinical Trial Summary

The investigators want to establish a new model of acute febrile disease by mimicking the conditions seen in hospitalized patients in regards to inflammation, immobilisation and fasting. In this new model of disease, healthy young adults will be given lipopolysaccharide (LPS) to induce endotoxemia and inflammation/fever and then fast and bedrest for 36 hours. Glucose, fat and protein metabolism will be investigated using clamp technique and tracer methodology together with intracellular signalling pathway activation in muscle and fat biopsies. This new model of disease will later be used in another study to investigate different protein supplement´s effect on muscle waste during acute febrile disease.

Clinical Trial Description

The investigators want to establish a new model of acute febrile disease by mimicking the conditions seen in hospitalized patients in regards to inflammation, immobilisation and fasting. In this new model of disease, healthy young adults will be given lipopolysaccharide (LPS) to induce endotoxemia and inflammation on study day 1 and then fast and bedrest for 36 hours (Study day 2). Glucose, fat and protein metabolism will be investigated using clamp technique and tracer methodology together with intracellular signalling pathway activation in muscle and fat biopsies. This new model of disease will later be used in another study to investigate different protein supplement´s effect on muscle waste during acute febrile disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03158363
Study type	Interventional
Source	University of Aarhus
Contact
Status	Completed
Phase	N/A
Start date	June 1, 2017
Completion date	August 31, 2017

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03754920` - Prolonged Fasting With Meditation and Mild Physical Exercise	N/A
Completed	`NCT05272332` - Gastric Ultrasound Prior to Extubation
Completed	`NCT04247464` - Short-term Fasting as an Enhancer of Chemotherapy: Pilot Clinical Study on Colorectal Carcinoma Patients	N/A
Completed	`NCT01067001` - Minocycline HCl Extended Release Tablets 135 mg Oral Bioequivalence Study	N/A
Completed	`NCT00757094` - Safety and Feasibility of Fasting While Receiving Chemotherapy	N/A
Completed	`NCT01506713` - Bioequivalence Study of Clopidogrel Tablets 75 mg of Dr. Reddy's Under Fasting Conditions	Phase 1
Completed	`NCT04514380` - Effect of Drinking Carbohydrate-containing Fluids on Gastric Residual Volume in Elderly Patients
Completed	`NCT05756868` - The Effect of Time-Restricted Feeding on Anthropometry, Biochemical Parameters, Diet Quality and Eating Behavior	N/A
Completed	`NCT05134207` - The Effect of Oral Carbohydrate Solution on Anxiety and Comfort in Patients Undergoing Hip Arthroplasty	N/A
Completed	`NCT05031598` - Long-term Fasting: Multi-system Adaptations in Humans	N/A
Recruiting	`NCT04501393` - Recommended Clear Fluid Intake Volume at 2 Hours Prior to Esophagogastroduodenoscopy for Adult Patients	N/A
Enrolling by invitation	`NCT04027478` - Can Fasting Decrease the Side Effects of Chemotherapy?	N/A
Completed	`NCT05219136` - Improve the Comfort, Safety and Quality of Upper Endoscopy by a Modified Fasting Protocol	N/A
Recruiting	`NCT04625608` - Effect of Premedicant Oral Paracetamol on Gastric Volume and pH	Phase 4
Not yet recruiting	`NCT02562638` - Pre-Procedural Fasting in Cardiac Intervention	N/A
Completed	`NCT01954836` - Short-Term Fasting During Chemotherapy in Patients With Gynecological Cancer- a Randomized Controlled Cross-over Trial	N/A
Completed	`NCT01949987` - Does Oral Intake Decreases Postoperative Pain Score in Children	N/A
Completed	`NCT01831700` - Bioequivalence Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg Under Fasting Conditions	Phase 1
Completed	`NCT01746719` - Bioequivalence Study of Etodolac Capsules USP 300 mg Under Fasting Condition	Phase 1
Completed	`NCT01713647` - Bioequivalence Study of Amlodipine / Losartan/ Hydrochlorothiazide of PHARMALINE, Lebanon Under Fastion Conditions	Phase 1