Therapeutic Targeting of Stress Factors in Ovarian Cancer Patients

Status Completed

Clinical Trial Summary

This research is looking at the effect of biobehavioral factors such as stress and whether these factors alter how the body responds to chemotherapy, one of the purposes of this study is to determine if the addition of a beta-blocker such as Propranolol (Inderal) is tolerable when given with chemotherapy in the treatment of newly diagnosed ovarian, fallopian tube, or primary peritoneal cancer. An additional purpose of the study is to understand if behavioral factors such as depression and anxiety can alter different blood markers that affect tumor vascularity. The Investigator wishes to determine whether the use of beta-blocker drugs such as Inderal, might alter these behavioral factors by drawing blood prior to and after the administration of Inderal as well as giving behavioral questionaires at different time points. Beta-blockers are commonly used for the treatment of hypertension, protection of the heart after a heart attack, and irregularities in heartbeats. Altering these factors might boost the immune system and affect other areas of cancer biology, thereby allowing the chemotherapy to be more effective. The significance of this research is that it may help improve our treatments of this disease in the future.

Clinical Trial Description

n/a

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Fallopian Tube Cancer
Fallopian Tube Neoplasms
Invasive Epithelial Ovarian Cancer
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Primary Peritoneal Carcinoma

Clinical Trial Details

NCT number	NCT01308944
Study type	Interventional
Source	Washington University School of Medicine
Contact
Status	Completed
Phase	Phase 1
Start date	August 2010
Completion date	August 2015

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT03393884` - Study of IMNN-001 (Also Known as GEN-1) With NACT for Treatment of Ovarian Cancer (OVATION 2)	Phase 1/Phase 2
Completed	`NCT04546373` - Niraparib as Maintenance Therapy in Patients With Platinum Sensitive Recurrent Ovarian Cancer
Active, not recruiting	`NCT05456685` - IMGN853 With Carboplatin in Second-line Treatment of FRα Expressing, Platinum-sensitive Epithelial Ovarian Cancer	Phase 2
Completed	`NCT01442051` - Acute Normovolemic Hemodilution in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer	N/A
Completed	`NCT02928549` - Factors Associated With the Use of a High Volume Cancer Center by Black Women With Ovarian Cancer: A Qualitative Study
Active, not recruiting	`NCT03648489` - Dual mTorc Inhibition in advanCed/Recurrent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer (of Clear Cell, Endometrioid and High Grade Serous Type, and Carcinosarcoma)	Phase 2
Not yet recruiting	`NCT04983550` - Efficacy and Safety of SG001 Combined With PLD in Patients With Platinum-resistant Relapsed EOC	Phase 2
Completed	`NCT02480374` - Study of Safety & Biological Activity of IP IMNN-001 (Also Known as GEN-1) With Neoadjuvant Chemo in Ovarian Cancer	Phase 1
Completed	`NCT01899599` - PankoMab-GEX™ Versus Placebo as Maintenance Therapy in Advanced Ovarian Cancer	Phase 2
Completed	`NCT01610206` - A Randomized Study of Safety and Efficacy of Pazopanib and Gemcitabine in Persistent or Relapsed Ovarian Cancer	Phase 2
Completed	`NCT03480750` - Trial of Trientine Plus Pegylated Liposomal Doxorubicin and Carboplatin in Epithelial Ovarian Cancer	Phase 1/Phase 2
Completed	`NCT01031381` - Study of RAD001 and Bevacizumab in Recurrent Ovarian, Peritoneal, and Fallopian Tube Cancer	Phase 2
Completed	`NCT01219777` - Neoadjuvant Chemotherapy IV Carboplatin With Weekly Paclitaxel \Bevacizumab for Primary Ovarian	Phase 1
Completed	`NCT00959582` - Positron Emission Tomography/Computed Tomography (PET/CT) in Relapsed Ovarian Cancer (MK-0000-143)	Phase 1
Completed	`NCT00768144` - Sunitinib in Recurrent and Refractory Ovarian, Fallopian Tube and Peritoneal Carcinoma	Phase 2
Completed	`NCT00801320` - Primary Tumor Harvest for the Purpose of Possible Use in a Future Clinical Trial in Patients With Ovarian, Fallopian Tube or Primary Peritoneal Cancer	N/A
Suspended	`NCT00753480` - A Study of D4064A Administered to Patients With Recurrent or Persistent Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancer	Phase 1
Completed	`NCT00702299` - Alimta® Plus Cisplatin & Paclitaxel Given Intraperitonelly; First Line Tx Stage III Ovarian Cancer	Phase 1
Recruiting	`NCT02349958` - Clinical Trial of Intraperitoneal Hyperthermic Chemotherapy	Phase 2
Terminated	`NCT00418093` - Oxaliplatin, Gemcitabine and Bevacizumab in Women With Recurrent Mullerian Carcinoma	Phase 2