Fallopian Tube Cancer Clinical Trial
Official title:
A Phase III Multicenter Prospective Randomized Controlled Clinical Trial of Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Advanced-Stage Epithelial Ovarian Cancer After Cytoreductive Surgery
This project is a multi-center, prospective, randomized controlled clinical observation the safety and efficacy of hyperthermic intraperitoneal chemotherapy in the treatment of advanced-stage epithelial ovarian cancer after cytoreductive surgery. Median recurrence-free survival is the primary end points of this project.
The current standard treatment for epithelial ovarian cancer, tubal cancer, and primary
peritoneal cancer is maximal cytoreductive surgery followed by intravenous chemotherapy with
or without intraperitoneal chemotherapy (IP). Recently, the organizations of SGO and ASCO
recommended that women with Fagotti score by laparoscopic exploration < 6 would benefit from
primary cytoreductive surgery followed by postoperative chemotherapy, and are likely to
attain optimal cytoreduction (residual lesion ≤ 1 cm).
Hyperthermia promotes chemotherapy to penetrate deeper into the cancer tissue. Therefore,
hyperthermic intraperitoneal chemotherapy (HIPEC) as newly postoperative chemotherapy after
primary cytoreductive surgery in the treatment of ovarian cancer could lead to higher
response rate and better survival outcomes.
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|---|---|---|---|
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