Clinical Trials Logo

Clinical Trial Summary

The incidence of fall in older adults aged 65 and over is estimated at 30%, and 50% of the people aged 80 and over with at least one fall a year. Falls are associated with significant morbidity and mortality. The origin falls is often multifactorial, involving intrinsic and extrinsic factors. Few studies have investigated the association with all antidepressants. Potential adverse effects of antidepressants such as hyponatremia, sedation, orthostatic hypotension, extrapyramidal symptoms are known risk factors for falls. Due to multimorbidity, polypharmacy including interaction risks, and aging-related changes in pharmacokinetic and pharmacodynamic of drugs, antidepressants may further increase this risk in older patients. Based on the World Health Organization global database, the main objective of this study is to investigate the association between antidepressants classes and the occurrence of falls reported in the database. A disproportionality analysis will be performed. It will aim to assess whether some classes of antidepressants, and within these classes some molecules, are associated with a greater risk of falls. A mediation analysis will also be performed. It will aim to examine some of the mediators involved in the association between antidepressants classes and falls.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms

  • Antidepressants Causing Adverse Effects in Therapeutic Use
  • Fall

NCT number NCT05628467
Study type Observational
Source University Hospital, Caen
Contact
Status Completed
Phase
Start date July 1, 2022
Completion date August 1, 2022

See also
  Status Clinical Trial Phase
Completed NCT04612842 - Engaging Older Adults in Fall Prevention Using Motivational Interviewing (MI) N/A
Enrolling by invitation NCT03297632 - Improving Muscle Strength, Mass and Physical Function in Older Adults N/A
Completed NCT06063187 - Technology-based Fall Risk Assessments for Older Adults in Low-income Settings
Withdrawn NCT04470895 - Impact of Drugs on the Risk of Falls in the Fracture Department of the Paris Saint-Joseph Hospital Group
Recruiting NCT05940779 - Relationship Between the Risk of Falls and Frailty, and the Effect of a Physical Exercise Program on These Conditions in the Elderly: a Randomized Crossover Clinical Trial. N/A
Not yet recruiting NCT05991037 - Relation Between Psychoactive Drugs Overdosage and Severity of Falls in Elderly People N/A
Not yet recruiting NCT05940636 - A Novel Combined Neuromodulation Therapy to Enhance Balance and Neuroplasticity N/A
Completed NCT03566719 - Effect of an Exercise Program on Risk of Fall in a Community Dwelling Older Adults N/A
Not yet recruiting NCT05702801 - Vibratory Stimulation to Improve Balance Recovery N/A
Not yet recruiting NCT04439097 - Effects of Multicomponent Physical Exercise Program and Mediterranean Diet in Alzheimer's Disease N/A
Recruiting NCT04108741 - Augmented Reality Treadmill Training in Patients With Parkinson's Disease N/A
Completed NCT04760392 - Goal-directed Mobilization of Medical Inpatients N/A
Not yet recruiting NCT03680014 - Remote Monitoring and Analysis of Gait and Falls Within an Elderly Population
Recruiting NCT04851405 - Implementing an Evidence-based Exercise Program to Reduce Falls in Community-dwelling Older Adults (Otago) N/A
Completed NCT05090774 - Integrating Fall Prevention Balance Exercises Into a Program for Older Adults With Peripheral Artery Disease (PAD): A Mixed Methods Feasibility Study N/A
Completed NCT04334746 - The Discriminative Ability of the Four Balance Measures for Fall History
Completed NCT03341728 - The Sensorimotor Locus of Balance Control in Elderly Gait N/A
Completed NCT05290571 - Modified Otago Exercise Program on Balance Performance N/A
Completed NCT04622657 - Validity Reliability of The Dubousset Functional Test in Parkinson Disease N/A
Completed NCT05863143 - Intervention on Reducing Risk of Falls Among Community Dwelling Older Adults in Selangor N/A