Glucose and Fructose Stimulated Brain Activity in Obese Subjects

Exploratory Behavior Clinical Trial

Official title:

Effects of Acute Glucose and Fructose Ingestion on Brain Activity in Obese Volunteers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02589613
• Other study ID #: fMRI Obese
• Status: Completed
• Phase: N/A
• First received: October 20, 2015
• Last updated: October 26, 2015
• Start date: October 2013
• Est. completion date: June 2014

Study information

• Verified date: October 2015
• Source: University Hospital, Basel, Switzerland
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: June 2014
• Est. primary completion date: June 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• right-handed healthy males, no drugs, non-smoking

Exclusion Criteria:

• drug abuse, smoker, left-handed, claustrophobia

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Exploratory Behavior

Intervention

Dietary Supplement:
• tap water
300ml tap water via nasogastric tube
• Glucose
300ml tap water with 75g Glucose via nasogastric tube
• Fructose
300ml tap water with 25g Fructose via nasogastric tube

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Basel, Switzerland

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow		changes from baseline to one hour after treatment	No
Secondary	Changes in plasma insulin		changes from baseline to one hour after treatment	No
Secondary	Changes in plasma glucose		changes from baseline to one hour after treatment	No
Secondary	Changes in plasma GLP-1		changes from baseline to one hour after treatment	No