Exertional Periodic Breathing Clinical Trial
Official title:
Chemoreflex Gain on Exercise
The purpose of this study is to assess chemoreflex gain on exercise.
Normally breathing is controlled by a reflex that responds to the levels of carbon dioxide
(CO2) in the blood. The change in breathing that results from a change in the blood's CO2
concentration is called the chemoreflex.
In heart failure, a condition where the heart muscle is damaged and can not pump as well,
this reflex is exaggerated. The result of this can be breathing conditions characterised by
patients hyperventilating at times and at other times taking very shallow breaths or even
stopping altogether. In the past the only way of measuring this chemoreflex was to get
patients to breathe into a large container and to rebreathe their exhaled air and allow the
CO2 to rise over time, whilst keeping the oxygen constant. The proportion by which the
ventilation increases with increasing carbon dioxide is the chemoreflex gain. Unfortunately,
because this test takes a long time to conduct, requires specialist knowledge and equipment
it has not been possible to measure this reflex on exercise.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science