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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05729841
Other study ID # 201021-A-08
Secondary ID
Status Completed
Phase
First received
Last updated
Start date November 28, 2020
Est. completion date April 1, 2024

Study information

Verified date May 2024
Source University of Exeter
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Little is known on the human adaptation to extreme endurance and with the increasing popularity in long duration events we seek to provide insight into the physiological and metabolic adaptation processes of ocean rowing. Rowing 12-18 hours a day will illicit a high energy expenditure and anecdotally people have lost large amounts of body weight and variable amounts of muscle mass, particularly in the lower limbs. This may provide insights and a potential new model to to study muscle unloading.


Description:

Previous research has investigated factors determining muscle loss through bed rest and limb immobilisation. These methods are limited in that some do not include inflammation or changes in nutrition, which have been shown to be key drivers of muscle loss. These studies aim to investigate a potentially new model of muscle unloading. Ocean rowing is an ultra-endurance sport where people spend 35-90 days at sea. Usually rowing for a minimum of 12 hours a day, in a 2-hour on/off shift pattern with daily food rations. Rowers lose body and muscle mass. There is likely to be low-grade inflammation, nutritional deficit, fatigue and rowers do not stand up for the entire crossing. Part 1 aims to quantify this muscle loss by inviting rowers in the annual 3000 mile Talisker Whisky Atlantic Challenge 2020 to take part. While part 2 aims to continue the work by measuring upper and core muscles as well as lower limb muscles from the first study with the aim of understanding how the body allocates resources in a hypocaloric, high energy expenditure environment. Muscle mass of the lower limbs of the rowers will be measured with ultrasound, as well as body mass, body composition, energy expenditure and nutritional intake, the week before the race and immediately after arrival in Antigua. As well as adding novel insights to the knowledge base around factors affecting ultra endurance performance, the results will then be used to inform future intervention studies aimed at preventing muscle loss.


Recruitment information / eligibility

Status Completed
Enrollment 60
Est. completion date April 1, 2024
Est. primary completion date February 16, 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Taking part in the Talisker Whisky Atlantic Challenge 2020 and 2021 Exclusion Criteria: - lower limb amputee musculoskeletal, metabolic, neurological disease pacemaker fitted

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Ocean row
the Talisker Whisky Atlantic Challenge annual ocean rowing race.

Locations

Country Name City State
United Kingdom University of Exeter Exeter Devon

Sponsors (1)

Lead Sponsor Collaborator
University of Exeter

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Energy Expenditure Amount of kcals expended per day 5-7 days in final week of row
Primary Calf Muscle thickness Pre - Post measurements of calf muscle thickness 5-7 weeks
Primary Energy Intake Amount of kcals consumed per day 5-7 days in final week of row
Secondary Difference in rate of muscle thickness loss between males and females Absolute and relative differences in energy balance, body mass loss or muscle loss 5-7 weeks
Secondary Difference in rate of muscle thickness loss in older vs younger rowers Are there any age-related differences in energy balance, body mass loss or muscle loss 5-7 weeks
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