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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05205538
Other study ID # 14279
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 25, 2022
Est. completion date February 28, 2023

Study information

Verified date April 2023
Source McMaster University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Sprint interval exercise training refers to brief repeated bouts of vigorous effort that are separated by short periods of recovery. Cardiac output refers to the amount of blood that is pumped out of the heart each minute. Research has shown that sprint interval exercise training can increase peak cardiac output - or the highest cardiac output that is achieved during strenuous exercise - but this response may be influenced by biological sex. The primary goal of this study is to determine whether the peak cardiac output response to 12 weeks of sprint interval exercise training differs between males and females. Cardiac output will be estimated using a non-invasive technique that involves breathing in a mixture of standardized gases. This research will help to determine whether biological sex influences the response of the heart to brief vigorous cycle exercise training.


Description:

The primary purpose of this study is to determine whether biological sex influences the peak cardiac output response to 12 weeks of sprint interval exercise training. Peak cardiac output will be determined non-invasively using an inert gas rebreathing technique. Each session of sprint interval exercise training will involve a 10-minute period of cycling on a stationary ergometer. The protocol will consist of a two-minute warm-up; three, 20-second 'all out' efforts that are separated by two minutes of recovery; and a three-minute cool down. Three sessions of training will be performed each week for a total of 12 weeks. Groups of male and female participants will be recruited and tested using best practice guidelines for sex-based comparisons of exercise responses. The study will advance knowledge regarding the potential for biological sex to influence the cardiovascular response to brief vigorous cycle exercise training.


Recruitment information / eligibility

Status Completed
Enrollment 21
Est. completion date February 28, 2023
Est. primary completion date February 28, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 35 Years
Eligibility Inclusion Criteria: - Being untrained based on a self-report of engaging in < 1 h of weekly moderate to vigorous physical activity based on the Canadian Society for Exercise Physiology Get Active Questionnaire. - Having an estimated cardiorespiratory fitness in the lower 50% of adults in the specified age range based on the online fitness calculator available at: www.worldfitnesslevel.org. - Females who are naturally cycling (i.e., not using any form of hormonal contraceptive) or are using a 2nd generation oral contraceptive. Exclusion Criteria: - Experiencing a condition that might preclude safe participation in physical activity and exercise, as determined by answering "Yes" to any question on Page 1 of the Canadian Society for Exercise Physiology Get Active Questionnaire. - Females with a positive pregnancy test.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Sprint interval exercise training
A 10-minute sprint interval exercise training protocol that is performed three times per week for a total of 12 weeks.

Locations

Country Name City State
Canada McMaster University Hamilton Ontario

Sponsors (1)

Lead Sponsor Collaborator
McMaster University

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary Peak cardiac output Peak cardiac output measured during exercise Change from baseline after 12 weeks of sprint interval exercise training
Secondary Peak oxygen uptake Peak oxygen uptake measured during exercise Change from baseline after 12 weeks of sprint interval exercise training
Secondary Flow mediated dilation Brachial artery flow mediated dilation Change from baseline after 4 and 12 weeks of sprint interval exercise training
Secondary Pulse wave velocity Central and peripheral pulse wave velocity Change from baseline after 4 and 12 weeks of sprint interval exercise training
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