Effects of Whey Protein and Collagen Supplementation

Exercise Clinical Trial

Official title:

Effects of Whey Protein and Collagen Supplementation on Muscle Mass and Function During Training in Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04213586
• Other study ID #: 3.058.958
• Status: Completed
• Phase: N/A
• Start date: September 1, 2019
• Est. completion date: December 5, 2019

Study information

• Verified date: January 2020
• Source: Universidade Norte do Paraná
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The present project aims to investigate the effects of high-quality protein (whey protein) vs. low-quality protein (collagen) on muscle mass and function (e.g., strength and power) during a 10-wk resistance training program in young adults. It will be tested the hypothesis that leucine-matched collagen should promote similar gains on muscle function and mass compared to whey protein supplementation.

Description:

The purpose of this study will be to investigate the effects of whey protein vs. leucine-matched collagen supplementation on muscle mass and function after a 10-wk resistance training program. Initially, all participants will be submitted for a 2-wk familiarization period, and then randomized into two groups (N = 11 / group): whey protein group and leucine-matched collagen group. The following variables will be assessed from pre-to post-training: anthropometric, muscle thickness from vastus lateralis and biceps brachii muscles using ultrasound, training load, mean power and peak torque for unilateral arm flexion exercise using a isokinetic dynamometer, countermovement vertical jump, nutritional intake, and testosterone-to-cortisol ratio . Shapiro-Wilk and Levine tests will be used to test the normality and homogeneity of the measurements, respectively. Two-way ANOVA (group x time) tests for repeated measures will be performed to assess changes over time and between groups for all dependent variables. Violation of sphericity will adjust using Greenhouse- Geyser correction. The Bonferroni post-hoc test will detect specific differences between groups. When appropriate, the percentage of change (∆%) will be reported according to the following equation: ∆% = [(pre-average post average) / pre-average mean] × 100. Values will be express as mean ± standard deviation. O significance level α will be 0.05.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: December 5, 2019
• Est. primary completion date: November 1, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Men and women aged 18-35 years

• To be eutrophic (not overweight or obese)

Exclusion Criteria:

• To present a history of musculoskeletal disorders

• Be attending a systematized weight training program for at least six months

• To make use of medicines that could affect muscle function.

• To have used ergogenic supplements and anabolic steroids for at least six months before study

• To have restrictions for exercises practice considering Physical Activity Readiness Questionnaire (PAR-Q) responses.

Related Conditions & MeSH terms

• Exercise
• Hypertrophy
• Muscle Strength
• Nutrition Therapy
• Resistance Training

Intervention

Dietary Supplement:
• Whey protein supplementation
35 g of whey protein (7 d/wk) during a 10-wk resistance training program (3 d/wk; 3 sets of 8-12 repetitions with an interval of 1-2 minutes between sets and exercises) involving the leg press, leg extension, and arm flexion exercises. The load will be adjusted weekly.
• Collagen supplementation
35 g of collagen (7 d/wk) + 2 g of leucine during a 10-wk resistance training program (3 d/wk; 3 sets of 8-12 repetitions with an interval of 1-2 minutes between sets and exercises) involving the leg press, leg extension, and arm flexion exercises. The load will be adjusted weekly.

Locations

Country	Name	City	State
Brazil	Universidade Norte do Paraná	Londrina	Paraná

Sponsors (2)

Lead Sponsor	Collaborator
Universidade Norte do Paraná	Universidade Estadual de Londrina

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in biceps brachii thickness	Measured by ultrasonography pre- and post-training	Baseline and after 10 weeks
Primary	Change in muscle strength by training load	Training load for leg press, knee extension, and arm flexion exercises	Baseline, 5 and 10 weeks
Primary	Change in vertical jump	Countermovement vertical jump performance will be assessed using the Smart Jump instrument	Baseline and after 10 weeks
Primary	Change in mean power	Mean power using a isokinetic dynamometer (BIODEX)	Baseline and after 10 weeks
Primary	Change in peak torque	Peak torque using a isokinetic dynamometer (BIODEX)	Baseline and after 10 weeks
Primary	Change in vastus lateralis thickness	Measured by ultrasonography pre- and post-training	Baseline and after 10 weeks
Secondary	Change in testosterone-to-cortisol ratio	Blood samples will be collected for analyse of the testosterone-to-cortisol ratio	Baseline and after 10 weeks
Secondary	Dietary intake	Dietary intake to be assessed using 3-day diet recalls.	Baseline, 2, 5, 10 weeks