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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02825823
Other study ID # H1601260
Secondary ID
Status Completed
Phase N/A
First received July 4, 2016
Last updated October 12, 2017
Start date July 2016
Est. completion date June 1, 2017

Study information

Verified date October 2017
Source University of British Columbia
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The ketone body beta-hydroxybutyrate is produced during prolonged fasting or exercise and can be used as an alternative fuel source. Exogenous beta-hydroxybutyrate, in the form of a ketone salt, is proposed to have ergogenic potential for high-intensity exercise performance but this has not been adequately studied. The purpose of this study is to determine whether supplementing with an acute dose of ketone salts can alter fuel use during exercise and improve exercise performance.


Recruitment information / eligibility

Status Completed
Enrollment 10
Est. completion date June 1, 2017
Est. primary completion date June 1, 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Male
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- Males aged 18-40

- Ability to understand and communicate in English to answer questionnaires and interact with the research assistant

- Physically active (defined by engaging in moderate-to-vigorous exercise at least 3 times per week, determined via validated questionnaire)

Exclusion Criteria:

- Diagnosed with diabetes or any other medical conditions that could affect metabolism.

- Diagnosed with heart disease or taking anti-hypertensive medications.

- Competitive endurance athlete (self-identified as engaged in specific endurance training in triathlon, cycling, or distance running and competing in races or competition)

- Recent (last 3 months) or current consumption of a low-carbohydrate ketogenic diet

- Current consumption of ketone supplements

- Any other contraindication to vigorous exercise (identified via physical activity readiness questionnaire [PAR-Q])

Study Design


Related Conditions & MeSH terms


Intervention

Dietary Supplement:
Ketone Salt

Placebo


Locations

Country Name City State
Canada University of British Columbia, Okanagan. Kelowna British Columbia

Sponsors (1)

Lead Sponsor Collaborator
University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome

Type Measure Description Time frame Safety issue
Primary Respiratory Exchange Ratio (RER) during cycling exercise The RER during 18 minutes of steady-state exercise 0-18 minutes
Secondary 10 km Cycling Time Trial Performance 10 km time trial performed on a stationary bicycle following 18 minutes of steady-state exercise Following 18 minutes of steady-state exercise
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