Exercise Clinical Trial
Official title:
Effects of Acute Exercise on (Myokine) Gene Expression in Human Skeletal Muscle
Rationale: Proteins released from muscle during and shortly after exercise, often referred
to as myokines, may be central to our understanding of the cross-talk during and after
exercise between skeletal muscles and other organs, in particular the liver. So far only a
few myokines are identified (e.g. IL-6, IL-8, IL-15, TNF-alpha). Taking into account the
role of these several known myokines in developing insulin resistance, revealing new
putative myokines might provide valuable information and a direction for future research on
the pathogenesis and treatment of type 2 diabetes mellitus.
Objective: The objective of the present study is to identify novel myokines, expression of
which is altered in skeletal muscle after a single bout of exercise.
Study design: experimental study. Study population: Ten healthy, male subjects between 40
and 60 years of age and BMI < 30 kg/m2, will participate in this study.
Intervention: A single exercise bout that consists of one hour one-legged cycling on a
adapted recumbent cycle ergometer at a submaximal rate. The non-exercising leg will serve as
control for the exercising leg.
Main study outcomes: Main study outcomes include upregulation of genes in skeletal muscle
after exercise (with a focus on genes encoding myokines) and changes of blood plasma levels
of selected proteins after exercise.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05156424 -
A Comparison of Aerobic and Resistance Exercise to Counteract Treatment Side Effects in Men With Prostate Cancer
|
Phase 1/Phase 2 | |
| Completed |
NCT05108181 -
Muscle Typology and Strength Training Adaptations
|
N/A | |
| Recruiting |
NCT05052918 -
The Effect of Exercise and Metformin on Carotid Intima-media Thickness in Patients With Prediabetes
|
N/A | |
| Completed |
NCT04508270 -
Significance of Early Mobilization After VATS-L
|
||
| Recruiting |
NCT04994340 -
Physical Activity Observatory of Castilla-La Mancha
|
||
| Completed |
NCT04815980 -
Impact of Pilates on Running Mechanics
|
N/A | |
| Completed |
NCT05189795 -
The Construction of Physical ACtivity Enhancement Scheme (PACES) in Hemodialysis Patients
|
||
| Completed |
NCT03683758 -
Effects of the FIFA11+ Warm-up Program on Speed, Agility, and Vertical Jump Performance in Adult Female Amateur Soccer Players
|
N/A | |
| Completed |
NCT05538520 -
Effects of Pilates Stretching on Flexibility, Strength, Power and Muscular Endurance
|
N/A | |
| Completed |
NCT06315036 -
Effects of Developmental Gymnastics on Preschoolers' Motor Skills
|
N/A | |
| Completed |
NCT03171064 -
Exercise as a Supportive Measure for Patients Undergoing Checkpoint-inhibitor Treatment
|
Phase 2 | |
| Recruiting |
NCT05496751 -
Response Variability to Exercise
|
N/A | |
| Not yet recruiting |
NCT05029804 -
Effect of Walking Exercise Training on Adherence to Disease Management and Metabolic Control in Diabetes
|
N/A | |
| Completed |
NCT04207359 -
Effects of Creatine Supplementation in Breast Cancer Survivors
|
N/A | |
| Completed |
NCT03832205 -
Validation of Respiratory Rate and Heart Rate Measurements by Capaciflectors Placed in Four Locations on the Chest
|
||
| Completed |
NCT04099654 -
The Effect of Core Stabilization Exercise Program in Obese Subjects Awaiting Bariatric Surgery
|
N/A | |
| Completed |
NCT03297567 -
Physical Therapy Guidelines For Hospitalized Elderly
|
N/A | |
| Completed |
NCT03477188 -
The Effects of Somatosensory and Vestibular Rehabilitation Additional Conventional Therapy on Balance in Patients With Acute Stroke.
|
N/A | |
| Recruiting |
NCT05956327 -
Insight Into Hippocampal Neuroplasticity in Schizophrenia by Investigating Molecular Pathways During Physical Training
|
N/A | |
| Recruiting |
NCT06018311 -
Exercising Together for Hispanic Prostate Cancer Survivor-Caregiver Dyads
|
N/A |