Comparing Acute Aerobic and Resistance Exercise

Exercise Physiology Clinical Trial

— CAARE  

Official title:

Effects of Age, Fitness Level, and Modality on Physiological Response to Acute Exercise

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT03794050
• Other study ID #: STUDY00001191
• Status: Terminated
• Phase: N/A
• Start date: December 18, 2018
• Est. completion date: March 31, 2020

Study information

• Verified date: March 2023
• Source: University of Houston
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the effect of age and fitness level on the physiological response to an acute bout of resistance or aerobic exercise.

Description:

Young and middle-aged to older adults who are physically active or not physically active will participate in two moderate to vigorous intensity exercise bouts: aerobic exercise and resistance training exercise. Blood will be collected to assess immune function and metabolism.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 35
• Est. completion date: March 31, 2020
• Est. primary completion date: March 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• "Young" Adults: ages 18-30

• "Older" Adults: ages 55-75 and if a female postmenopausal

• Participants classified as "trained" must participate in at least 30 minutes of moderate to vigorous intensity cardiovascular activity at least 3 days per week and engage in resistance training for all of the major muscle groups approximately 2 days / week. They must have upheld this activity for the past 3 months

• Participants classified as "untrained" must be participating in less than 30 minutes of moderate to vigorous intensity cardiovascular activity and less than 2 days of resistance training per week for at least the last 3 months.

Exclusion Criteria:

• Have any contraindications to moderate to vigorous exercise

• Range of motion restrictions that would prevent them from participating in aerobic or resistance training with proper form (they must be ambulatory)

• aking medications (prescription or over the counter) known to influence immune function, including daily NSAID's, beta blockers, statins, bisphosphonates, or steroids.

• Have known cardiovascular, respiratory, metabolic, or renal disease, with the exception of controlled hypertension (as defined by resting BP below 140/90) and/or controlled asthma (self-reported).

• Be pregnant

• Be unable to complete all visits (i.e. must not be planning to leave the Houston area long-term before concluding their participation in the study which will span several weeks)

• Fall outside of a BMI range of (18.5 - 30)

• Consume alcohol or recreational drugs for 24h prior to visits

• Older women cannot be pre-menopausal (must have not had a menses for at least 12 months)

• Unable to speak or read English

• Participants must not have scheduling conflicts that would prevent them from reporting to the laboratory of integrated physiology 4 times over the course of the study

Related Conditions & MeSH terms

• Exercise Physiology

Intervention

Other:
• Resistance training exercise
randomized complete crossover for acute resistance training exercise session
• Aerobic training exercise
randomized complete crossover for acute aerobic exercise training exercise session

Locations

Country	Name	City	State
United States	University of Houston	Houston	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Houston

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Monocyte subset and function	Flow cytometry to classify monocyte subsets and in vitro LPS stimulation to assess monocyte function	Pre-resistance training (RT) exercise, change from pre-RT exercise to immediately post-RT exercise, change from pre-RT exercise to 1hr post-RT exercise, change from immediately post-RT exercise to 1hr post-RT exercise
Primary	Monocyte subset and function	Flow cytometry to classify monocyte subsets and in vitro LPS stimulation to assess monocyte function	Pre-aerobic training (AT) exercise, change from pre-AT exercise to immediately post-AT exercise, change from pre-AT exercise to 1hr post-AT exercise, change from immediately post-AT exercise to 1hr post-AT exercise
Primary	Monocyte subset and function	Flow cytometry to classify monocyte subsets and in vitro LPS stimulation to assess monocyte function	compare pre-RT to pre-AT
Primary	Monocyte subset and function	Flow cytometry to classify monocyte subsets and in vitro LPS stimulation to assess monocyte function	compare immediately post-RT to immediately post-AT
Primary	Monocyte subset and function	Flow cytometry to classify monocyte subsets and in vitro LPS stimulation to assess monocyte function	compare 1hr post-RT to 1hr post-AT
Primary	NK cell function	Flow cytometry to identify NK cells and in vitro activity to assess NK activity	Pre-resistance training (RT) exercise, change from pre-RT exercise to immediately post-RT exercise, change from pre-RT exercise to 1hr post-RT exercise, change from immediately post-RT exercise to 1hr post-RT exercise
Primary	NK cell function	Flow cytometry to identify NK cells and in vitro activity to assess NK activity	Pre-aerobic training (AT) exercise, change from pre-AT exercise to immediately post-AT exercise, change from pre-AT exercise to 1hr post-AT exercise, change from immediately post-AT exercise to 1hr post-AT exercise
Primary	NK cell function	Flow cytometry to identify NK cells and in vitro activity to assess NK activity	compare pre-RT to pre-AT
Primary	NK cell function	Flow cytometry to identify NK cells and in vitro activity to assess NK activity	compare immediately post-RT to immediately post-AT
Primary	NK cell function	Flow cytometry to identify NK cells and in vitro activity to assess NK activity	compare 1hr post-RT to 1hr post-AT
Primary	Circulating relative and absolute counts of T cell subsets	Flow cytometry to identify T cell subsets	Pre-resistance training (RT) exercise, change from pre-RT exercise to immediately post-RT exercise, change from pre-RT exercise to 1hr post-RT exercise, change from immediately post-RT exercise to 1hr post-RT exercise
Primary	Circulating relative and absolute counts of T cell subsets	Flow cytometry to identify T cell subsets	Pre-aerobic training (AT) exercise, change from pre-AT exercise to immediately post-AT exercise, change from pre-AT exercise to 1hr post-AT exercise, change from immediately post-AT exercise to 1hr post-AT exercise
Primary	Circulating relative and absolute counts of T cell subsets	Flow cytometry to identify T cell subsets	compare pre-RT to pre-AT
Primary	Circulating relative and absolute counts of T cell subsets	Flow cytometry to identify T cell subsets	compare immediately post-RT to immediately post-AT
Primary	Circulating relative and absolute counts of T cell subsets	Flow cytometry to identify T cell subsets	compare 1hr post-RT to 1hr post-AT
Secondary	Serum cortisol	ELISA to measure circulating cortisol (serum)	Pre-resistance training (RT) exercise, change from pre-RT exercise to immediately post-RT exercise, change from pre-RT exercise to 1hr post-RT exercise, change from immediately post-RT exercise to 1hr post-RT exercise
Secondary	Serum cortisol	ELISA to measure circulating cortisol (serum)	Pre-aerobic training (AT) exercise, change from pre-AT exercise to immediately post-AT exercise, change from pre-AT exercise to 1hr post-AT exercise, change from immediately post-AT exercise to 1hr post-AT exercise
Secondary	Serum cortisol	ELISA to measure circulating cortisol (serum)	compare pre-RT to pre-AT
Secondary	Serum cortisol	ELISA to measure circulating cortisol (serum)	compare immediately post-RT to immediately post-AT
Secondary	Serum cortisol	ELISA to measure circulating cortisol (serum)	compare 1hr post-RT to 1hr post-AT