The Effect of Curcumin Supplementation on Recovery From Exercise-induced Muscle Damage

Exercise Induced Muscle Damage Clinical Trial

Official title:

The Effect of Curcumin Supplementation on Recovery From Exercise-induced Muscle Damage

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05346211
• Other study ID #: ASE22HELCON
• Status: Not yet recruiting
• Phase: N/A
• Start date: May 1, 2022
• Est. completion date: September 30, 2023

Study information

• Verified date: April 2022
• Source: St Mary's University College
• Contact: Luke Hughes, PhD
• Phone: +447920004214
• Email: luke4.hughes[@]northumbria.ac.uk
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Recent evidence suggests that curcumin supplementation may reduce muscle inflammation, oxidative markers, and muscle damage. The most favourable dosage to elicit these ergogenic effects are yet to be established; both 750mg & 1500mg has been shown to be effective. Curcumin supplementation has been ingested in numerous different ways however, no previous research to date has used curcumin in a hydrolysed (drinkable) format. The aim of this study is to investigate whether hydrolysed curcumin can reduce indices of muscle damage and improve recovery, whilst also examining a potential dose-response effect.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 36
• Est. completion date: September 30, 2023
• Est. primary completion date: September 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

Inclusion criteria are as follows:

• between the age of 18-35

• non-smoker

• no previous history of cardiovascular, respiratory, or neurological problems

• not taking anticoagulant medication

• injury-free in the 3 months prior to scheduled participation in the study

Exclusion Criteria:

Exclusion criteria include:

• hypertension (<140/80)

• any blood diseases or clotting issues,

• injury, or previous injury in <3 months

Related Conditions & MeSH terms

• Exercise Induced Muscle Damage

Intervention

Dietary Supplement:
• Curcumin
Curcumin Supplementation

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
St Mary's University College

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood markers	Blood samples will be taken for analysis of markers of IL-6, IL-1ß, TNF-a, IL-1, IL-4, IL-10 and CK will be taken	Baseline
Primary	Blood markers	Blood samples will be taken for analysis of markers of IL-6, IL-1ß, TNF-a, IL-1, IL-4, IL-10 and CK will be taken	immediately post muscle damage intervention
Primary	Blood markers	Blood samples will be taken for analysis of markers of IL-6, IL-1ß, TNF-a, IL-1, IL-4, IL-10 and CK will be taken	24 hours post
Primary	Blood markers	Blood samples will be taken for analysis of markers of IL-6, IL-1ß, TNF-a, IL-1, IL-4, IL-10 and CK will be taken	48 hours post
Primary	Blood markers	Blood samples will be taken for analysis of markers of IL-6, IL-1ß, TNF-a, IL-1, IL-4, IL-10 and CK will be taken	72 hours post
Primary	Ford and Fort	Capillary sample Ford and Fort tests	Baseline
Primary	Ford and Fort	Capillary sample Ford and Fort tests	Immediately post muscle damage intervention
Primary	Ford and Fort	Capillary sample Ford and Fort tests	24 hours post
Primary	Ford and Fort	Capillary sample Ford and Fort tests	48 hours post
Primary	Ford and Fort	Capillary sample Ford and Fort tests	72 hours post
Primary	Soreness	Perceived muscle soreness scale - Visual analouge scale	Baseline
Primary	Soreness	Perceived muscle soreness scale - Visual analouge scale	Immediately post muscle damage intervention
Primary	Soreness	Perceived muscle soreness scale - Visual analouge scale	24 hours post
Primary	Soreness	Perceived muscle soreness scale - Visual analouge scale	48 hours post
Primary	Soreness	Perceived muscle soreness scale - Visual analouge scale	72 hours post
Primary	Soreness	BORG CR-10 scale	Baseline
Primary	Soreness	BORG CR-10 scale	Immediately post muscle damage intervention
Primary	Soreness	BORG CR-10 scale	24 hours post
Primary	Soreness	BORG CR-10 scale	48 hours post
Primary	Soreness	BORG CR-10 scale	72 hours post
Primary	Soreness	Pressure pain threshold	Baseline
Primary	Soreness	Pressure pain threshold	Immediately post muscle damage intervention
Primary	Soreness	Pressure pain threshold	24 hours post
Primary	Soreness	Pressure pain threshold	48 hours post
Primary	Soreness	Pressure pain threshold	72 hours post
Primary	Muscle Structure	Muscle swelling - thigh girth + Ultrasound measurement	Baseline
Primary	Muscle Structure	Muscle swelling - thigh girth + Ultrasound measurement	Immediately post muscle damage intervention
Primary	Muscle Structure	Muscle swelling - thigh girth + Ultrasound measurement	24 hours post
Primary	Muscle Structure	Muscle swelling - thigh girth + Ultrasound measurement	48 hours post
Primary	Muscle Structure	Muscle swelling - thigh girth + Ultrasound measurement	72 hours post
Primary	Muscle Function	maximal strength	Baseline
Primary	Muscle Function	maximal strength	Immediately post muscle damage intervention
Primary	Muscle Function	maximal strength	24 hours post
Primary	Muscle Function	maximal strength	48 hours post
Primary	Muscle Function	maximal strength	72 hours post
Primary	Muscle Function	Muscular endurance	Baseline
Primary	Muscle Function	Muscular endurance	Immediately post muscle damage intervention
Primary	Muscle Function	Muscular endurance	24 hours post
Primary	Muscle Function	Muscular endurance	48 hours post
Primary	Muscle Function	Muscular endurance	72 hours post