The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage

Exercise-induced Muscle Damage Clinical Trial

Official title:

The Effect of Ischemic Pre-Conditioning on the Rate of Recovery Following Exercise-Induced Muscle Damage: a Randomized Control Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01907841
• Other study ID #: IPCEIMD001
• Status: Completed
• Phase: N/A
• First received: July 15, 2013
• Last updated: March 5, 2014
• Start date: July 2013
• Est. completion date: November 2013

Study information

• Verified date: March 2014
• Source: St Mary's University College
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs.

Therefore the purpose of this study is to:

1. Quantify the use of IPC in recovery following EIMD.

2. Identify any effect of IPC during recovery on muscle function

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: November 2013
• Est. primary completion date: November 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Physically Active Males

Exclusion Criteria:

• Muscular skeletal disorders

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Exercise-induced Muscle Damage

Intervention

Other:
• Ischemic Preconditioning

Locations

Country	Name	City	State
United Kingdom	St Marys Umiversity College	London

Sponsors (1)

Lead Sponsor	Collaborator
St Mary's University College

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change from baseline in maximal voluntary contraction	Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition.; The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions.	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	No
Secondary	Change from baseline in Creatine kinase	Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser.; The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	No
Secondary	Change from baseline in Limb girth	Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position.; The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	No
Secondary	Chnage from baseline in Vertical jump	Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally.; The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	No
Secondary	Change from baseline in Muscle soreness	Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful).; The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions	pre exercise, 24 hours post, 48 hours post and 72 hours post exercise	No