Different Domains of Executive Function Dual Task Walking on Brain Activation and Gait Performance in Healthy Adults

Executive Function Clinical Trial

Official title:

The Effects of Different Domains of Executive Function Dual Task Walking on Brain Activation and Gait Performance in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04905186
• Other study ID #: 202103125RINC
• Status: Completed
• Start date: August 1, 2021
• Est. completion date: May 23, 2022

Study information

• Verified date: June 2022
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The aim of this study is to investigate the effects of different domains of executive function (EF) during dual task walking condition on brain activation and gait performance in healthy adults. There are two experiments will be conducted in this study. Experiment 1 is a pilot study to determine the same level of difficulty in 3 EF domains, including inhibition, working memory and cognitive flexibility. Experiment 2 is carried out to investigate the effects of 3 different domains of EF which difficulties are controlled on gait performance and brain activation in dual task condition. 10 subjects will perform Stroop test (2s/3s/4s to change question), backward digit spans (3/4/5 digits) and naming test in Experiment 1. In Experiment 1, the primary outcome is the correct response speed (CRS) while secondary outcome will be the brain activity. In Experiment 2, 30 subjects will perform the single cognitive task A (SCTA, Stroop test), single cognitive task B (SCTB, backward digit spans), single cognitive task C (SCTC, naming test), single walking task (SWT), dual task A (DTA, walking while performing cognitive task A), dual task B (DTB, walking while performing cognitive task B) and dual task C (DTC, walking while performing cognitive task C). The CRS, gait performance, brain activity and the dual task costs (DTC) will be recorded in the Experiment 2. Brain activities in prefrontal cortex (PFC), premotor cortex (PMC) and supplementary motor area (SMAs) will be measured by functional near-infrared spectroscopy (fNIRS) during this study. One-way ANOVA with Tukey post-hoc test will be performed to establish the effect of different type of executive task on CRS or the brain activity. The differences of gait parameters and brain activity in different condition in the Experiment 2 will be examined by one-way ANOVA with repeated measured. Furthermore, the Pearson correlation coefficient will be used to examine the correlation of brain activation and executive function performance or gait parameters.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 39
• Est. completion date: May 23, 2022
• Est. primary completion date: May 23, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

• 20-30 years (Experiment 1 & 2)

• Mini-Mental State Examination (MMSE) score greater than 24 points (Experiment 1 & 2)

• ability to walk 10 meters independently without an assistive device (Experiment 2)

Exclusion Criteria:

• any neurologic, orthopedic or psychological diseases (Experiment 1 & 2)

• color vision deficiency (Experiment 1 & 2)

• had the fall experiences within 6 months before the study (Experiment 2)

Related Conditions & MeSH terms

• Executive Function
• Neurosciences

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Experiment 1: Executive function performance- correct response speed (CRS)	CRS is the number of correct responses per unit time (correct responses/ second)	Day 1
Primary	Experiment 2: Executive function performance- correct response speed (CRS)	CRS is the number of correct responses per unit time (correct responses/ second)	Day 1
Primary	Experiment 2: walking performance- gait speed	The unit is m/s	Day 1
Primary	Experiment 2: walking performance- cadence	The unit is steps/min	Day 1
Primary	Experiment 2: walking performance- stride length	The unit is m	Day 1
Primary	Experiment 2: dual task performance- dual task costs(DTC) in mobility	DTC in mobility = (single task gait speed - dual task gait speed) / single task gait speed x 100%	Day 1
Primary	Experiment 2: dual task performance- dual task costs(DTC) in executive function	DTC in executive function = (single task correct response speed - dual task correct response speed) / single task correct response speed x 100%	Day 1
Primary	Experiment 2: dual task performance- combine mean of dual task costs(DTC)	combine mean of DTC = ( DTC in mobility + DTC in executive function) / 2	Day 1
Secondary	Experiment 1: Brain activation over prefrontal cortex	The unit is micro mole (µmol). A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics, including oxygenated-hemoglobin and de-oxygenated hemoglobin.	Day 1
Secondary	Experiment 1: Brain activities over supplementary motor area	The unit is micro mole (µmol). A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics, including oxygenated-hemoglobin and de-oxygenated hemoglobin.	Day 1
Secondary	Experiment 1: Brain activities over premotor cortex	The unit is micro mole (µmol). A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics, including oxygenated-hemoglobin and de-oxygenated hemoglobin.	Day 1
Secondary	Questionnaire in Chinese version	used for the participants to sort the task by the difficulty level based on their own experiences.The participants will be asked to grade the tasks from 1-10 scale. Scale one is the simplest and 10 is the hardest.	Day 1
Secondary	Experiment 2: Brain activities over prefrontal cortex	The unit is micro mole (µmol). A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics, including oxygenated-hemoglobin and de-oxygenated hemoglobin.	Day 1
Secondary	Experiment 2: Brain activities over supplementary motor area	The unit is micro mole (µmol). A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics, including oxygenated-hemoglobin and de-oxygenated hemoglobin.	Day 1
Secondary	Experiment 2: Brain activities over premotor cortex	The unit is micro mole (µmol). A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics, including oxygenated-hemoglobin and de-oxygenated hemoglobin.	Day 1