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NCT06243588 Clinical Trial

Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

Ewing Sarcoma Clinical Trial

Official title:
Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT06243588
Other study ID # ProEwing
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date January 25, 2024
Est. completion date July 31, 2024

Study information
Verified date January 2024
Source Istituto Ortopedico Rizzoli
Contact Costantino Errani
Phone 0516366
Email costantino.errani@ior.it
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

assess whether there is a correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma. Identification of reliable prognostic factors could help to identify high-risk patients, which may require a different treatment and follow up.

Recruitment information / eligibility
Status Recruiting
Enrollment 400
Est. completion date July 31, 2024
Est. primary completion date July 31, 2024
Accepts healthy volunteers No
Gender All
Age group 2 Years and older
Eligibility Inclusion Criteria: - Male and female patients treated at Rizzoli Orthopaedic Institute between 01/01/1991 and 31/12/2021 - Age = 2 years - Diagnosis of Ewing Sarcoma - Patients with available clinical and imaging data Exclusion Criteria: - At least one inclusion criterion not met

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• clinical records review
review the medical records, radiological imaging, and histological data of these patients

Locations
Country Name City State
Italy IRCCS Itituto Ortopedico Rizzoli Bologna BO

Sponsors (1)
Lead Sponsor Collaborator
Istituto Ortopedico Rizzoli

Country where clinical trial is conducted

Italy, 

References & Publications (2)

Grunewald TGP, Cidre-Aranaz F, Surdez D, Tomazou EM, de Alava E, Kovar H, Sorensen PH, Delattre O, Dirksen U. Ewing sarcoma. Nat Rev Dis Primers. 2018 Jul 5;4(1):5. doi: 10.1038/s41572-018-0003-x. — View Citation

Pressman BD, Tourje EJ, Thompson JR. An early CT sign of ischemic infarction: increased density in a cerebral artery. AJR Am J Roentgenol. 1987 Sep;149(3):583-6. doi: 10.2214/ajr.149.3.583. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Correlation Correlation between some factors (age, sex, tumor volume, tumor site, chemotherapy-induced necrosis, radiation and biomarkers) and overall survival (OS) and relapse-free survival (RFS) in patients with Ewing sarcoma. At baseline (Day 0)
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