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Eculizumab for Prevention and Treatment of Kidney Graft Reperfusion Injury

End-Stage Renal Disease Clinical Trial

Official title:
Study of Eculizumab for Prevention and Treatment Reperfusion Injury in Kidney Transplantation.

Clinical Trial Summary

Study of eculizumab ability to correct the reperfusion injury of the kidney allograft.

Clinical Trial Description

Based on experimental data and supportive observations in humans associating complement gene upregulation with ischemic reperfusion injury, it is hypothesized that C5 cleavage is a key step in the pathogenesis of ischemic reperfusion injury following transplantation. It was further hypothesized that eculizumab, antibody that blocks C5 cleavage in humans will be an effective prophylactic agent to prevent ischemic reperfusion injury in high risk recipients. For testing this hypothesis, this study is a pilot prospective study to test the efficacy of eculizumab in preventing the development of reperfusion injury and contribute graft survival. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01756508
Study type Interventional
Source Russian Academy of Medical Sciences
Contact
Status Completed
Phase Phase 2
Start date September 1, 2012
Completion date December 1, 2017
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