End Stage Renal Disease Clinical Trial
OBJECTIVES: I. Evaluate the separate and combined skeletal effects of recombinant human
growth hormone (GH) and calcitriol in patients with adynamic renal osteodystrophy.
II. Assess whether calcium-regulated changes in parathyroid hormone secretion predict
changes in bone formation.
III. Characterize the response to GH in cancellous bone and in growth plate cartilage in
patients with secondary hyperparathyroidism during calcitriol therapy.
Status | Completed |
Enrollment | 109 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 1 Year to 18 Years |
Eligibility |
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- - End-stage renal disease undergoing continuous cycling peritoneal dialysis at the University of California at Los Angeles --Prior/Concurrent Therapy-- - No concurrent prednisone - No concurrent cytotoxic agents - At least 12 months since parathyroidectomy --Patient Characteristics-- - Other: No documented history of poor compliance with medical treatment regimens |
Allocation: Randomized, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | University of California Los Angeles School of Medicine | Los Angeles | California |
Lead Sponsor | Collaborator |
---|---|
National Center for Research Resources (NCRR) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of California, Los Angeles |
United States,
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