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Esophagus Adenocarcinoma clinical trials

View clinical trials related to Esophagus Adenocarcinoma.

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NCT ID: NCT06030180 Recruiting - Barrett Esophagus Clinical Trials

CLUE: CLinical Utility Study of EsoGuard

PR-0410
Start date: February 23, 2023
Phase: N/A
Study type: Interventional

Utilize real-world data from the commercial use of EsoGuard testing on samples collected with EsoCheck (EC/EG) to evaluate the impact of EsoGuard results on health care provider's decision for endoscopy referral. Assess patient compliance with recommendations for upper endoscopy, and relationship of compliance to positive EsoGuard results.

NCT ID: NCT05713838 Recruiting - Clinical trials for Esophagus Adenocarcinoma

Organ Preservation With Durvalumab-based Immunotherapy in Combination With Chemoradiation as Definitive Therapy for Early Stage Esophageal Adenocarcinoma With Indication for Radical Surgery

Start date: August 28, 2023
Phase: Phase 2
Study type: Interventional

The present clinical trial is a prospective, investigator-initiated, single-arm, open-label, multicenter phase II trial investigating whether a definite organ preservation therapy consisting of the combination of durvalumab with chemoradiation is an efficient and safe treatment option for early stage, cT1 and cT2N0, esophageal adenocarcinoma with indication for radical surgery.

NCT ID: NCT05591053 Recruiting - Esophageal Cancer Clinical Trials

Utility and Usability of ActivSight™ Laser Speckle Imaging in Visualization of Tissue Perfusion and Blood Flow During Esophageal Surgery in Humans

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

ActivSight™ combines an innovative form factor and proprietary software to deliver precise, objective, real-time visualization of blood flow and tissue perfusion intraoperatively for laparoscope-based surgery. A small adaptor that fits between any existing laparoscope and camera systems and a separate light source placed along any current commercial system will deliver objective real-time tissue perfusion and blood flow information intraoperatively. Primary Objective: To determine the feasibility of ActivSight™ in detecting and displaying tissue perfusion and blood flow in the conduit and foregut anastomoses in esophageal resection/reconstructive surgery. The investigators will compare the precision and accuracy among the naked eye inspection, ICG and LSCI in assessing the vascularity of the conduit.

NCT ID: NCT05476796 Recruiting - Clinical trials for Gastric Adenocarcinoma

Oxaliplatin ± Nivolumab in Combination With Trifluridine/Tipiracil or 5-fluorouracile in Frail Patients With Advanced, Recurrent or Metastatic Gastric, Oesophageal or Gastroesophageal Junction Cancer

LOGICAN
Start date: June 23, 2023
Phase: Phase 2
Study type: Interventional

Oxaliplatin ± nivolumab in combination with trifluridine/tipiracil or 5-fluorouracile (5-FU) in frail patients with advanced, recurrent or metastatic gastric, oesophageal or gastroesophageal junction cancer.

NCT ID: NCT04018872 Recruiting - Clinical trials for Gastroesophageal Junction Adenocarcinoma

Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Start date: June 24, 2019
Phase: Phase 2
Study type: Interventional

Esophageal cancer, which has a low 5-year overall survival rate for all stages (<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to inhibit various pathways involved in esophageal cancer tumorigenesis including Hh and AKT. In this phase II clinical trial, the investigators aim to evaluate the effect of itraconazole as a neoadjuvant therapy following standard of care chemoradiation in the treatment of locoregional esophageal and gastroesophageal junction carcinomas.