CYP2C19 Genotype Predictor of Gastric Acid Suppression

Status Withdrawn

Clinical Trial Summary

If CYP2C19 genotype can predict the efficacy of healing erosive esophagitis and gastric acid secretion in patients taking once a day omeprazole.

Clinical Trial Description

Proton pump inhibitors are metabolized through the CYP2C19 hepatic enzyme system. Several variant genotypes of this enzyme exist which may lead to decreased, normal or increased metabolism of the proton pump inhibitor. With alteration of metabolism, the degree of gastric acid suppression achieved and efficacy in treating reflux could be affected. For example, Asian populations who have low activity of CYP2C19, commonly need lower doses of proton pump inhibitors to manage gastroesophageal reflux because of more sustained blood levels and availability of the drug. Theoretically, those patients who are rapid metabolizers would receive less effective treatment with proton pump inhibitors ;

Study Design

Related Conditions & MeSH terms

Esophagitis

Clinical Trial Details

NCT number	NCT01824199
Study type	Interventional
Source	Mayo Clinic
Contact
Status	Withdrawn
Phase	Early Phase 1
Start date	March 2013
Completion date	November 2016

View Details

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