Esophageal Resection Candidates Clinical Trial
Official title:
Preoperative Inspiratory Muscle Training to Prevent Postoperative Pneumonia in Patients Undergoing Esophageal Resection
The PREPARE study is the first multicenter randomized controlled trial to evaluate the hypothesis that preoperative inspiratory muscle training leads to decreased pulmonary complications in patients undergoing esophageal resection.
Rationale: Esophageal resection is associated with high incidences of postoperative
pulmonary pneumonia. Numbers of 30% are reported in literature. Postoperative complications
can result in prolonged hospital stay and increased health care costs. In cardiac surgery
patients a reduction of postoperative pneumonia of 50% is reported as a result of a
preoperative inspiratory muscle training program. While in some surgical centers IMT is
already used in the preoperative phase in patients undergoing esophageal resection, the
effect of this promising intervention has not yet been investigated in a randomised and
controlled study design in large surgical populations other than cardiac surgery.
Primary objective: Investigate the effect of a preoperative inspiratory muscle training
program on the incidence of postoperative pneumonia in patients undergoing esophageal
resection.
Study design: Prospective multicenter randomised controlled clinical trial.
Main study parameters/endpoints: A significant reduction in incidence of postoperative
pneumonia.
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