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Esophageal Motility Disorders clinical trials

View clinical trials related to Esophageal Motility Disorders.

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NCT ID: NCT06329583 Recruiting - Dysphagia Clinical Trials

Establishing Pressures at the EGJ During Diaphragmatic Breathing Using High-resolution Esophageal Manometry

Start date: May 10, 2024
Phase: N/A
Study type: Interventional

The goal of this study is to determine which position, maneuvers or combination thereof generates the highest pressure at the EGJ as assessed by high-resolution esophageal manometry and thus greater or more robust contraction of the diaphragm.

NCT ID: NCT06314893 Recruiting - Clinical trials for Esophageal Motility Disorders

Establishing a Correlation Between HRM and UGI MM Studies

MMvsMANO
Start date: August 24, 2022
Phase:
Study type: Observational

A retrospective and prospective cohort, quantitative data collection with the goal of comparing preoperative High Resolution Manometry(HRM) results to Upper Gastrointestinal Marshmallow(UGI MM) results, in patients undergoing preoperative esophageal motility assessments. The aim of this study is to establish a correlation between HRM and UGI MM in order to create a clinically supported gold standard measurement for preoperative esophageal motility assessment.

NCT ID: NCT05913011 Not yet recruiting - Clinical trials for Esophageal Motility Disorders

Prevalence of IEM Among Upper GIT Symptoms

Start date: August 2023
Phase:
Study type: Observational

- detect the prevalence of IEM among upper git symptom . - clarify the role of HRM in diagnosis of refractory upper GIT symptoms.

NCT ID: NCT05905016 Recruiting - Gastroparesis Clinical Trials

Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders

POEM
Start date: October 1, 2021
Phase:
Study type: Observational [Patient Registry]

This is prospective data recording study. All patients will receive standard medical care and no experimental interventions will be performed.

NCT ID: NCT05604261 Not yet recruiting - Clinical trials for Gastroesophageal Reflux

A Study of Anaprazole Sodium Enteric-coated Tablets in the Treatment of Reflux Esophagitis

Start date: December 2022
Phase: Phase 2
Study type: Interventional

A phase 2, randomized, double-blind, double-dummy, positive drug parallel controlled, multicenter trial to evaluate efficacy and safety of within 8 weeks (including 8 weeks) treatment of Anaprazole 40mg QD, 60mg QD compared with Rabeprazole 20mg QD in patients with reflux esophagitis.

NCT ID: NCT05455359 Not yet recruiting - Clinical trials for Gastro Esophageal Reflux

Gastrointestinal Dysmotility on Aspiration Risk

Start date: July 18, 2022
Phase: Phase 4
Study type: Interventional

The hypothesis of this study is that esophageal and gastric dysmotility increase the risk of developing aspiration-associated symptoms in children with neurologic impairment. The investigators are conducting a ten week cross over study comparing prucalopride to famotidine for the treatment of aspiration-associated symptoms.

NCT ID: NCT05402462 Not yet recruiting - Clinical trials for Esophageal Motility Disorders

Esophageal Motility Disorders in Patients With Non-cardiac Chest Pain at Assiut University Hospital

Start date: June 30, 2022
Phase:
Study type: Observational

to determine the prevalence and distribution of esophageal motility disorders in NCCP patients who presented after a negative cardiac evaluation and underwent esophageal manometry, esophageal pH monitoring

NCT ID: NCT05380791 Recruiting - Clinical trials for Esophageal Motility Disorders

Effect of Esophageal Contractile Reserve on Changes in Esophageal Motility and Symptoms After ARS in Patients With GERD

Start date: April 22, 2022
Phase:
Study type: Observational [Patient Registry]

rapid swallow (MRS) can assess the contractile reserve capacity of the oesophageal body and identify and diagnose oesophageal motility disorders, but the impact of preoperative oesophageal reserve capacity on postoperative symptoms and motility in patients with GERD remains unclear. The aim of this study was to assess the effect of pre-operative oesophageal reserve capacity on post-reflux symptoms and motility in patients with GERD by using a high-resolution oesophageal manometry-based provocation test, MRS, to track pre-operative ineffective oesophageal motility (IEM).

NCT ID: NCT05272046 Active, not recruiting - Clinical trials for Esophageal Motility Disorders

Monopolar and Bipolar Current RFA Knife in POEM

Start date: February 22, 2022
Phase: N/A
Study type: Interventional

Per Oral Endoscopic Myotomy (POEM) is performed for various esophageal muscular disorders, including achalasia and other spastic esophageal conditions. It is performed with the standard endoscope and involves dissecting the esophageal muscle sphincter. The procedure is typically completed using standard monopolar energy, which are effective, but can be associated with post-procedural pain. More importantly, frequent exchange of various instruments are required in order to cut the right layers and to stop bleeding. The Speedboat-RSD is FDA approved for dissection of various tissue within the gastrointestinal tract tract but only a few studies have evaluated its use in POEM. Currently, the investigators have been performing EGD with POEM procedures using Speedboat-RSD as a standard of care procedure. The investigators would like to compare the performance of the standard monopolar ERBE knife to the bipolar Speedboat-RSD knife in POEM. The investigators hypothesize the bipolar knife will allow for efficient completion of the POEM procedure with less post procedural pain.

NCT ID: NCT05132816 Recruiting - Clinical trials for Gastroesophageal Reflux

High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux

Start date: January 24, 2022
Phase: N/A
Study type: Interventional

This is a combined retro- and prospective, monocentric study. All patients who underwent or are planned for laparoscopic partial fundoplication (180° anterior or 270° posterior) between 2020-2023 are assessed for preoperative ineffective esophageal motility (IEM). The main hypothesis is, that preoperative oesophageal motility disorders, especially hypo-contractility or failed peristalsis, are caused by gastro-oesophageal reflux. Therefore, postoperative manometry after partial wrap fundoplication (270° posterior, 180° anterior) shows a decrease in comparison to preoperative motility disorders. The primary objective of this study is to examine the postoperative esophageal motility in patients with known preoperative motility disorders. Secondary endpoints are the presence of other oesophageal motility disorders pre- vs. postoperatively (including new onset disorders), the assessment of the Gastrointestinal Symptom Rating Scale (GSRS) pre- vs. postoperatively, and more. If IEM is present preoperatively, patients are contacted at least 1 year after surgery and will be informed about the study and asked to participate. In case of agreement, they are invited to the study site. They undergo high-resolution manometry 18-24 months postoperatively (study intervention).