Esophageal Cancer Clinical Trial
Official title:
Serologic Response to Pneumococcal Vaccination Among Esophageal Cancer Patients With High Grade Lymphopenia After Chemoradiation
To learn how radiation treatment may affect your responses to vaccines against pneumonia.
Primary Objectives - Determine the impact of Grade IV radiation-induced lymphopenia on serologic responses to pneumococcal vaccination. Secondary Objectives - Determine the impact of chemoradiation on serologic responses to pneumococcal vaccination. - Determine the impact of radiation modality on serologic responses to pneumococcal vaccination. - Determine the impact of radiation modality on systemic immunity. - Determine the incidence of pneumonia among patients treated with a pneumococcal vaccine. - Determine the impact of radiation modality on pathologic response. - Determine the impact of radiation modality on intratumoral immunity. - Determine the relationship between changes in systemic and intratumoral immunity and clinical outcomes (i.e., incidence of pneumonia and pathologic response) - Determine the impact of tumor histology on serologic responses to pneumococcal vaccination. ;
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