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Clinical Trial Summary

The primary aim of the PERSuaDER-trial is to evaluate the effect of SDD on infectious complications after esophagectomy, focussed on the prevention of pneumonia


Clinical Trial Description

Esophagectomy is a complex surgical procedure, associated with significant morbidity and mortality rates. Most postoperative complications are caused by infections (10-30%). These are thought to arise from (micro-)aspiration of bacteria residing in the oropharyngeal and gastrointestinal (GI) tract, leading to (respiratory) infections. Selective decontamination of the digestive tract (SDD) is a prophylactic antibiotic strategy that aims to prevent postoperative infections. Pathogenic aerobic gram-negative rods and yeasts tract are reduced, while anaerobic, protective microbiota are preserved. SDD has been shown to lower the risk for respiratory infections in an intensive care setting. Establishing SDD as effective addition to the standard care of esophagectomy patients is expected to increase their chance of survival. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05865743
Study type Interventional
Source Radboud University Medical Center
Contact Justin Grootenhuis, MD
Phone +31655740313
Email justin.grootenhuis@radboudumc.nl
Status Not yet recruiting
Phase Phase 3
Start date June 2024
Completion date December 2027

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