| Eligibility |
Inclusion Criteria:
1. Able to provide written informed consent and can understand and agree to comply with
the requirements of the study and the schedule of assessments
2. Age = 18 years but 80 years or younger on the day of signing the informed consent
form.
3. Histologically proven esophageal squamous cell cancer or adenocarcinoma.
4. De novo diagnosis, have not received prior treatment
5. AJCC 8. T1N1 or T2-4aN0-2M0 resectable disease
6. ECOG Performance Status = 1
7. Adequate organ function as indicated by the following laboratory values
a. Patients must not have required a blood transfusion or growth factor support = 14
days before sample collection at screening for the following i. Absolute neutrophil
count (ANC) = 1.5 x 109/L ii. Platelets = 100 x 109/L iii. Hemoglobin = 90 g/L b.
Serum creatinine = 1.5 x ULN (upper limit of normal) or estimated Glomerular
Filtration Rate = 60 mL/min/1.73 m2 c. Serum total bilirubin = 1.5 x ULN (total
bilirubin must be < 3 x ULN for patients with Gilberts syndrome). d. AST and ALT = 3 x
ULN
8. Females of childbearing potential must be willing to use a highly effective method of
birth control for the duration of the study, and = 120 days after the last dose of
tislelizumab, and have a negative urine or serum pregnancy test = 7 days before the
first dose of tislelizumab.
9. Non-sterile males must be willing to use a highly effective method of birth control
for the duration of the study and for = 120 days after the last dose of tislelizumab
Exclusion Criteria:
10. Unresectable disease either T4b or M1 per AJCC8
11. Deemed inoperable for any reason by attending surgeon
12. Any prior treatment directed at the tumor except biopsy.
13. Active autoimmune diseases such as SLE, RA requiring systemic immunosuppression or
history of autoimmune diseases that may relapse.
14. Any active malignancy = 2 years before first dose of study drug, except for cancer
that has been treated curatively (e.g., resected basal or squamous cell skin cancer,
superficial bladder cancer, carcinoma in situ of the cervix or breast)
15. Any condition that required systemic treatment with either corticosteroids (> 10 mg
daily of prednisone or equivalent) or other immunosuppressive medication = 14 days
before tislelizumab. Note: Patients who are currently or have previously been on any
of the following steroid regimens are not excluded:
1. Adrenal replacement steroid (dose = 15 mg daily of prednisone or equivalent)
2. Topical, ocular, intra-articular, intranasal, or inhaled corticosteroid with
minimal systemic absorption
3. Short course (= 7 days) of corticosteroid prescribed prophylactically (e.g., for
contrast dye allergy) or for the treatment of a non-autoimmune condition (e.g.,
delayed-type hypersensitivity reaction caused by contact allergen)
16. Laboratory test abnormalities in potassium, sodium, or corrected calcium > Grade 1
despite standard medical management
17. History of interstitial lung disease, non-infectious pneumonitis or uncontrolled
diseases including pulmonary fibrosis, acute lung diseases, etc.
18. Severe chronic or active infections requiring systemic antibacterial, antifungal or
antiviral therapy, including tuberculosis infection, etc.
19. A known history of HIV infection not controlled with anti-retroviral therapy
20. Patients with untreated chronic hepatitis B or chronic hepatitis B virus (HBV)
carriers whose HBV DNA is > 500 IU/mL or patients with active hepatitis C virus (HCV)
should be excluded. Note: Inactive hepatitis B surface antigen (HBsAg) carriers,
treated and stable hepatitis B (HBV DNA < 500 IU/mL), and cured hepatitis C patients
can be enrolled
21. Prior allogeneic stem cell transplantation or organ transplantation
22. Any of the following cardiovascular risk factors:
1. Cardiac chest pain, defined as moderate pain that limits instrumental activities
of daily living, = 28 days before first dose of tislelizumab and chemotherapy
2. Any history of heart failure meeting New York Heart Association (NYHA)
Classification III or IV (Appendix 6) = 6 months
3. Any event of ventricular arrhythmia = Grade 2 in severity = 6 months prior to
initiation of treatment on study.
23. A history of severe hypersensitivity reactions to chimeric or humanized antibodies or
fusion proteins
24. Has received radiation therapy within 4 weeks, chemotherapy, immunotherapy (e.g.,
interleukin, interferon, thymosin), or any investigational therapies within 14 days or
5 half lives (whichever is shorter) of the first study drug administration
25. Was administered a live vaccine = 4 weeks before tislelizumab Note: Seasonal vaccines
for influenza are generally inactivated vaccines and are allowed.
Intranasal vaccines are live vaccines and are not allowed. The mRNA vaccine for
SARSCoV2 is allowed if the second dose is administered two weeks before study drug is
administered.
26. Underlying medical conditions (including laboratory abnormalities) or alcohol or drug
abuse or dependence that, will be unfavorable for the administration of study drug or
affect the explanation of drug toxicity or AEs or result in insufficient or might
impair compliance with study conduct.
27. Concurrent participation in another therapeutic clinical study.
28. History of allergy to platinum or taxane
29. Li-Fraumeni Syndrome where radiation is contraindicated
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