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Clinical Trial Summary

This is an open-label, multicenter, phase Ib study to evaluate the safety, tolerability, and preliminary efficacy of AN0025 in combination with chemoradiotherapy (CRT) in patients with locally advanced/locally recurrent esophageal cancer.


Clinical Trial Description

This study will enroll patients with unresectable locally advanced/locally recurrent esophageal cancer or esophagogastric junction cancer to assess the safety and tolerability of AN0025 at 250mg QD and 500mg QD combined with concurrent chemoradiotherapy to fix the MTD or RP2D. At RP2D level, another 20 patients with unresectable locally advanced/locally recurrent esophageal cancer or esophagogastric junction cancer will be enrolled at PR2D dose level to explore the preliminary efficacy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05191667
Study type Interventional
Source Adlai Nortye Biopharma Co., Ltd.
Contact Jianming Xu, MD
Phone 010-66937876
Email Jianmingxu2014@163.com
Status Recruiting
Phase Phase 1
Start date January 18, 2022
Completion date December 2025

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