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Assessment of Response to nCRT for GEJ Cancer Using a Fully Integrated PET/MRI — Escape  

Esophageal Cancer Clinical Trial

Official title:
Prediction of Assessment of Response to Neoadjuvant Chemo-Radio-Therapy (nCRT) for Esophageal and Gastroesophageal Junction Cancer (GEJ) Using a Fully Integrated PET/MRI

Clinical Trial Summary

Evaluate the potential role of PET/MRI as a predictor of esophageal and junctional cancers in response to neoadjuvant chemoradiotherapy (nCRT).

Clinical Trial Description

This is a prospective, observational single center study which plans to enroll patients with biopsy proven potentially resectable esophageal or junctional cancer scheduled to receive nCRT (CROSS regimen) prior to surgery. The study aims to evaluate Routine pre-treatment work-up includes PET to stage the tumour extension. - PET/MRI (Magnetic resonance imaging) will replace the PET component of CT(computed tomography) - An additional intermediate 18-FDG (Fluorodeoxyglucose) PET/MRI will be performed during nCRT - Post nCRT imaging, as required prior to surgery, will be PET/MRI six weeks after treatment completion. - 8-12 weeks post nCRT completion surgery will be performed, based on each patient's performance status and response to nCRT - Histopathological samples of the excised tumor and lymph nodes will be used for diagnosis, staging and description of qualitative and quantitative parameters Routine clinical and radiological follow-up for 24 months (for the scope of this study) will follow the standard clinical workflow assigned to this group of patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04359732
Study type Interventional
Source IRCCS San Raffaele
Contact Francesco De Cobelli, MD
Phone +3926432529
Email decobelli.francesco@hsr.it
Status Recruiting
Phase N/A
Start date May 8, 2020
Completion date June 30, 2025
View Details
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