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Clinical Trial Summary

A single arm, open-label pilot study is designed to determine the safety, tolerability and effectiveness of personalized mRNA tumor vaccine encoding neoantigen in Patients with advanced esophageal cancer and non-small cell lung cancer


Clinical Trial Description

Primary objectives: Assessing the safety and tolerability of mRNA personalized tumor vaccines encoding neoantigen for unresectable or metastatic advanced esophageal and non-small cell lung cancers with standard treatment failure or no standard treatment. Secondary objectives: Preliminary observation of the efficacy of mRNA personalized tumor vaccines encoding neoantigen for unsurgically resected or metastatic advanced esophageal and non-small cell lung cancers with standard treatment failure or no standard treatment. Time of tumor progression (TTP); Disease Control Rate (DCR); Objective Remission Rate (ORR); Overall Survival (OS). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03908671
Study type Interventional
Source Stemirna Therapeutics
Contact Li Yang
Phone 0371-66295320
Email yanglizzuyl@163.com
Status Recruiting
Phase N/A
Start date October 18, 2019
Completion date December 31, 2025

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