Tissue Collection Protocol for Gastroesophageal Cancers

Esophageal Cancer Clinical Trial

Official title:

Tissue Collection for Gastro-esophageal Cancer Primary Cell Line Establishment

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02495337
• Other study ID #: 14-8514
• Status: Recruiting
• Start date: May 2015
• Est. completion date: December 2030

Study information

• Verified date: March 2024
• Source: University Health Network, Toronto
• Contact: Frances Allison
• Phone: 416-340-5446
• Email: Frances.Allison[@]uhn.ca
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This proposed collection of primary tumor cells lines will benefit esophageal cancer research within the University Health Network. This collection of gastro-esophageal tumor samples will be used to grow primary tumor cell lines, which will provide researchers with ready samples of various gastro-esophageal cancers. This will help to address the issue of access to these cell lines due to the limited number of patients with gastro-esophageal tumors, and high rates of contamination.

Description:

Samples will be collected during surgery, EGD, or other biopsy. The surgeon will resect a sample for the research coordinator and/or fellow who will collect the sample and take it back to the lab for processing. Samples collected will be in excess of standard samples that are sent for pathology. The surgeon will make sure that excess samples will not affect pathological diagnosis. In addition samples may be purchased from the National Cancer Institute's Cooperative Human Tissue Network.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 100
• Est. completion date: December 2030
• Est. primary completion date: December 2030
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients with esophagogastric cancer and/or GERD +/- Barrett's esophagus who will undergo surgery and/or EGD as standard of care.

Exclusion Criteria:

• Patients who are not well enough to undergo surgery or EGD as standard of care.

Related Conditions & MeSH terms

• Esophageal Cancer
• Esophageal Neoplasms

Intervention

Other:
• Tissue Collection

Locations

Country	Name	City	State
Canada	University Health Network: Toronto General Hospital	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
University Health Network, Toronto

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Effectively culture, proliferate, and store primary gastro-esophageal cell lines in order to create a bank of primary esophageal / gastric cancers for research purposes	The primary objective of this study is to determine an effective way to culture, proliferate, and store primary gastro-esophageal cell lines in order to create a bank of primary esophageal / gastric cancers or GERD with/without Barrett's esophagus for research purposes, in addition we will be creating organoids.	Ongoing