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Chemoradiotherapy for Advanced Esophageal Cancer — PaRCUS  

Esophageal Cancer Clinical Trial

Official title:
A Phase 2 Study of Palliative Chemo-Radiotherapy With Carbo-Taxol in Non-Curative Cancer of the Esophagus

Clinical Trial Summary

This study aims to show that the addition of carboplatin and paclitaxel chemotherapy to a palliative course of external beam radiation treatment improves both dysphagia relief and patient quality of life in patients with unresectable esophageal cancer.

Clinical Trial Description

Patients with carcinoma of the esophagus not suitable for definitive radical treatment who have symptomatic dysphagia requiring locoregional palliation, and who have no contra-indications to chemo-radiotherapy will be offered Carboplatin (AUC 2) and paclitaxel (50 mg/m2) intravenously on days 1 and 8 concurrent with external beam radiation therapy of 30Gy/10 fractions over two weeks where the primary goal is relief of dysphagia and other outcomes include toxicity, quality of life and metabolomics. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02297217
Study type Interventional
Source AHS Cancer Control Alberta
Contact Marc Kerba, MD
Phone 403 521 3164
Email marc.kerba@albertahealthservices.ca
Status Recruiting
Phase Phase 2
Start date November 21, 2019
Completion date April 30, 2025
View Details
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