Esophageal Cancer Clinical Trial
Official title:
Using "PET Response Criteria in Solid Tumors (PERCIST)" in Evaluating Response to Neoadjuvant Chemoradiotherpy for Esophageal Cancer
This study is aimed to evaluate the effectiveness of 18F-FDG PET in the initial staging,
therapy planning, and therapeutic response monitoring for esophageal cancer patients.
Purpose:
1. The incremental staging information by using 18F-FDG PET
2. The impact of the PET results on the patients' subsequent therapy planning
3. To compare treatment response using RECIST criteria and FDG PET results.
Background: Esophageal cancer is one of the leading malignancies in Taiwan. Accuracy tumor
staging can direct to appropriate therapy planning and provide prognostic implications.
Positron emission tomography (PET) with [18F]-fluoro-2-deoxy-D-glucose (FDG) has been shown
to have better N staging and prognostic stratification abilities than conventional imaging
modalities, such as endoscopic ultrasonography (EUS) and CT.
Purpose: This study is aimed to evaluate the effectiveness of 18F-FDG PET in the initial
staging, therapy planning, and therapeutic response monitoring for esophageal cancer
patients.
Method: Patients with pathological proven esophageal cancer, age 20-90 year-old, will be
included in this study. Each patient will receive a baseline PET study. For those patients
who received pre-operative CCRT, another PET will be performed 1-4 weeks after completion of
CCRT.
Primary outcome: 1. The incremental staging information by using 18F-FDG PET 2. The impact
of the PET results on the patients' subsequent therapy planning 3. To compare treatment
response using RECIST criteria and FDG PET results.
Secondary outcome: To correlate the PET response rate and the patients' disease free
survival and overall survival.
;
Observational Model: Case-Only, Time Perspective: Prospective
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