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Clinical Trial Summary

There is a need for more effective therapy for patients with esophageal squamous cell carcinoma who developed disease progression after first line therapy. Currently, there is no standard second-line therapy for this disease. BKM-120 is a pan-PI3K inhibitor currently tested in clinical trials. In a cellular model of oral-esophageal carcinogenesis, it has shown that EGFR overexpression activated PI3/AKT pathway. Therfore, there is interest to see the efficacy and safety of BKM120 in this setting.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01806649
Study type Interventional
Source Prince of Songkla University
Contact
Status Terminated
Phase Phase 2
Start date July 1, 2013
Completion date April 30, 2016

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