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CHFR Methylation Status Esophageal Cancer Study — J10130  

Esophageal Cancer Clinical Trial

Official title:
A Phase 2 Study of Paclitaxel With Cisplatin Versus Fluoropyrimidine With a Platinum Agent for Neoadjuvant Therapy in Operable Esophageal Cancer Based on CHFR Methylation Status in Diagnostic Biopsies

Clinical Trial Summary

This is a Phase 2 Study of Paclitaxel with Cisplatin versus Fluoropyrimidine with a Platinum Agent for Neoadjuvant Therapy in Operable Esophageal Cancer Based on CHFR Methylation Status in Diagnostic Biopsies.

Clinical Trial Description

Primary Objectives

• To determine the rate of pathological complete response when the inclusion of paclitaxel in neoadjuvant therapy is based on the presence or absence of CHFR methylation in diagnostic biopsy specimens.

Secondary Objectives

- To determine the survival outcome with this treatment strategy.

- To determine time to disease progression with this treatment strategy.

- To determine the agreement between tumor CHFR methylation and detection in plasma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01372202
Study type Interventional
Source Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Contact
Status Terminated
Phase Phase 2
Start date June 2011
Completion date October 1, 2014
View Details
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