Erysipelas Clinical Trial
Official title:
Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean Fever
Erysipelas-like erythema (ELE) and arthritis are common manifestations affecting the ankle in Familial Mediterranean Fever. Musculoskeletal ultrasound examination of the ankle has never been performed during an episode of ELE. We hypothesize that ELE is associated with underlying musculoskeletal pathology. In order to support this hypothesis, ankle musculoskeletal ultrasound will be performed within 24 hours of onset of ELE in 15 patients diagnosed with FMF. Results will be correlated with clinical parameters, serum inflammatory markers, and ankle radiography.
Erysipelas-like erythema (ELE) is the pathognomonic cutaneous manifestation of familial
Mediterranean fever (FMF). It typically presents with painful, well-demarcated, and
unilateral erythema overlying the ankle, and resolves spontaneously within 24 to 72 hours.
Its incidence varies from 1% to 48% in the literature, depending on gender and ethnicity.
Joint involvement during FMF is more common than ELE, affecting between 17% and 77% of
patients. It is most often monoarticular and involves the ankles in almost half of cases.
Concomitant ELE is described in up to 43% of patients. However, the overlap between the
clinical presentation of ELE and ankle arthritis in FMF poses a diagnostic challenge.
Musculoskeletal ultrasound is a simple and sensitive technique for the evaluation of
articular and peri-articular structures. Only one study described sonographic articular
involvement in FMF. In 29 asymptomatic patients, an increased prevalence of knee effusion,
retrocalcaneal bursitis and medial tenosynovitis of the ankle was noted compared with the
control group. Irrespective of joint involvement, an increased prevalence of enthesopathy has
also been documented by ultrasound in patients with FMF, thus strengthening its association
with spondyloarthropathy. However, no study has evaluated by ultrasound the articular and
peri-articular involvement of the ankle during an episode of ELE. To date, the treatment of
ELE involves ankle offloading and administration of analgesics. By allowing a better
understanding of its pathogenesis, sonographic confirmation of articular and peri-articular
involvement of the ankle during an episode of ELE will potentially allow to optimize its
therapeutic management.
The study population involves over 600 patients with FMF followed at Tenon Hospital, which is
part of the French Reference center for rare auto-inflammatory diseases and amyloidosis
(CEREMAIA). Eligible patients will be contacted by mail or email to inform them of the study.
Those interested in participating will be advised to contact the investigators by email or
phone at the onset of ELE. Patients presenting with ELE during their visit in the internal
medicine department of Tenon Hospital will also be screened for eligibility.
A visit between the participant and attending physician will be scheduled within 24 hours of
the onset of ELE. The usual management of ELE will not be altered. The visit will include a
questionnaire and physical examination to assess the presence of typical manifestations of
FMF attacks, such as chest and/or abdominal pain, as well as to exclude systemic toxicity in
favor of an alternative infectious diagnosis. It will involve a blood test for complete blood
count and C-reactive protein measurement to confirm the inflammatory syndrome, as well as an
x-ray of the ankles to exclude an underlying structural pathology. Analgesics will be
prescribed for symptomatic relief. The patient will be advised to go the emergency room if
ELE and/or fever persist beyond 72 hours, or if symptoms suggestive of an infectious process
develop (significant worsening of general state, cardiorespiratory symptoms, pre-syncope or
syncope, etc).
The inclusion visit for the study will be integrated to this medical consultation. Once free
and informed consent is obtained, the following clinical data will be collected: age, sex,
weight, height, body mass index, ethnicity, age at onset of FMF symptoms, age at diagnosis of
FMF, genotype, frequency of attacks, diagnosis of amyloidosis, spondyloarthropathy,
inflammatory bowel disease and/or vasculitis, previous episodes of ankle arthritis, duration
and location of ELE at inclusion, total duration of ELE, presence of fever, serositis and/or
myalgia, and current treatment for FMF. In search of potential confounding factors for
sonographic musculoskeletal abnormalities, the following data will also be collected:
professional occupation, physical activity (type and frequency), presence of pes planus or
cavus, pre-existing ankle pain, and chronic ankle edema. Sonographic evaluation of the
articular and periarticular structures of the two ankles will be performed using the Samsung
UGEO H60 echograph, in operation since 2016. In order to ensure reproducibility, the
evaluation will be completed by a single examiner throughout the study.
Following the inclusion visit, a follow-up by email or phone will be done within one week of
inclusion in order to confirm the exact duration of ELE. This information will allow us to
confirm the diagnosis of ELE, which normally resolves spontaneously within 72 hours, in
contrast to its main differential diagnosis, namely erysipelas. Thereafter, there will be no
additional follow-up as part of this study.
The patient inclusion phase will last 8 months, followed by 3 months of data analysis. We
estimate that 8 months will be sufficient to recruit 15 patients among our study population.
The number 15 was arbitrarily chosen because FMF is a rare disease, and the incidence of ELE
in this population is highly variable and therefore poorly defined in the literature.
Regarding data analysis, clinical, biological, radiographic and sonographic data will be
presented as medians (± interquartile interval) when these are continuous variables, and as
absolute numbers with proportion when these are categorical variables. Sonographic and
radiographic findings will be compared between the ankles ipsilateral and contralateral to
ELE. Continuous variables will be compared with the Mann-Whitney test. Categorical variables
will be compared with the Fisher test. In order to determine whether clinical and
paraclinical parameters are correlated with the presence of sonographic musculoskeletal
pathologies, univariate and multivariate analyses will be performed using a logistic
regression model. A p value ≤ 0.05 will be considered statistically significant.
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