Intranasal TXA for Anterior Epistaxis in the Emergency Department

Status Suspended

Clinical Trial Summary

The objective of this study is to evaluate the efficacy of and patient satisfaction with the use of intranasal tranexamic acid (TXA) for anterior nosebleeds in the emergency department (ED).

Clinical Trial Description

Pledget soaked in either saline or TXA will be applied to the bleeding nare of the patient presenting with anterior epistaxis. After fifteen minutes, the pledget will be removed and patient reassessed.

Informed consent will be obtained prior to patient enrollment.

Enrolled patients will be placed in one of two groups: either the group receiving a cotton pledget soaked in (0.9%) saline or (100mg/1mL) TXA. Patients will initially be asked to gently blow their nose to remove any clots. Group 1 will receive the saline soaked pledget. After fifteen minutes the pledget will be removed. If patient continues to bleed within a reevaluation period of fifteen minutes, this will be deemed a 'failure' and the examiner will pack the nose with the method of his or her choice. Group 2 will receive the TXA soaked pledget and the procedure will continue like Group 1.

Patient satisfaction will be assessed in both groups during ED stay and one week after ED stay. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04054687
Study type	Interventional
Source	Mercy Health Ohio
Contact
Status	Suspended
Phase	Phase 2
Start date	November 7, 2019
Completion date	May 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05334017` - Xylometazoline and Cocaine for Nasal Vasoconstriction	Phase 4
Not yet recruiting	`NCT04519463` - The Effect of Local Anesthesia With Lidocaine During Insertion and Removal of Nasal Packing	Early Phase 1
Recruiting	`NCT01886768` - Double Versus Single Pledget Nasal Anesthesia for Transnasal Endoscopy	N/A
Recruiting	`NCT00390663` - A Prospective Randomised Controlled Trial of Management of Recurrent Nosebleeds in Children	Phase 4
Completed	`NCT02285634` - The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.	N/A
Completed	`NCT01485224` - Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia	Phase 2
Completed	`NCT00793117` - The Effect of Packing in Post Operative Management of FESS	Phase 4
Recruiting	`NCT06259292` - Comprehensive HHT Outcomes Registry of the United States (CHORUS)
Recruiting	`NCT03850964` - Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz)	Phase 2/Phase 3
Recruiting	`NCT05281952` - Medico-economic Evaluation of Management Strategies for Severe Epistaxis	N/A
Completed	`NCT03360045` - Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis	Phase 4
Completed	`NCT04279288` - The Roles of Hilotherapy in the Management of Epistaxis and Nasal Fractures	N/A
Completed	`NCT03912051` - Assessment of Performance and Safety of an Asymmetric Balloon in the Treatment of Intranasal Bleeding Managed in an Emergency Setting	N/A
Not yet recruiting	`NCT02677467` - Correlation Between Epistaxis and Cardiovascular Disease	N/A
Completed	`NCT01314274` - Intranasal Submucosal Bevacizumab for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT)	Phase 2
Terminated	`NCT01051427` - Control of Epistaxis With Surgiflo	N/A
Completed	`NCT00863356` - Trial of a Novel Chitosan Hemostatic Sealant in the Management of Complicated Epistaxis	N/A
Recruiting	`NCT05269849` - Sirolimus for Nosebleeds in HHT	Phase 2
Not yet recruiting	`NCT05343650` - NOVAPAK Nasal Packing in Shellfish Allergic Patients	Phase 4
Not yet recruiting	`NCT02963129` - Treatment of Nasal Staphylococcus Aureus Colonization in Patients With HHT	Phase 3