Epilepsy Clinical Trial
Official title:
Onchocerciasis-Associated Epilepsy, an Explorative Case-control Study With Viral Metagenomic Analysis of Onchocerca Volvulus.
This is an exploratory case control study with the aim to compare the Onchocerca volvulus virome between persons with onchocerciasis-associated epilepsy (OAE) and persons with onchocerciasis but without epilepsy. The main question we want to address is: Is there a virus contained in the O. volulus worm that may have a pathogenic role in causing OAE. In Maridi County, South Sudan, 20 persons with OAE with onchocerciasis nodules, and 20 age- and village-matched controls without OAE will be enrolled in a nodulectomy study.The adult O. volvulus worms will be extracted from the nodules and a viral metagenomic study of the worms. The O. volvulus virome of persons with and without OAE will be compared.
Status | Not yet recruiting |
Enrollment | 40 |
Est. completion date | December 31, 2024 |
Est. primary completion date | July 1, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 12 Years to 35 Years |
Eligibility | Inclusion Criteria: - Onchocerciasis nodules - Age 12-35 years old - informed consent signed - Living in Maridi County, Western Equatorial State, South Sudan Exclusion Criteria: - below the age of 12 |
Country | Name | City | State |
---|---|---|---|
South Sudan | Amref Health Africa | Juba | Central |
Lead Sponsor | Collaborator |
---|---|
Universiteit Antwerpen | Amref Health Africa |
South Sudan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The O. volvulus virome of persons with onchocerciasis-associated epilepsy (OAE) and of persons with onchocerciasis but without epilepsy | The type of virusses present in the O. volvulus worm present in the nodules of persons with OAE and in nodules of persons without epilepsy | 1 day |
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