Epilepsy Clinical Trial
Official title:
Auditory Stimulation Effect on Spindles and Sleep Dependent Learning in Rolandic Epilepsy
The investigators are recruiting children with Rolandic epilepsy and children without epilepsy (aged 4 years old and above) for a non-invasive brain imaging study using Magnetic Resonance Imaging (MRI), Magnetoencephalography/Electroencephalography (MEG/EEG), and experimental tasks. The investigators hope to determine the brain circuits and brain rhythms affected in these children and ultimately identify new treatment options for childhood epilepsy patients.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 4 Years to 18 Years |
Eligibility | Inclusion Criteria: 1. Ages 4-18 years 2. Diagnosed with childhood epilepsy with centrotemporal spikes (CECTS) or Rolandic epilepsy by child neurologist 3. Has EEG with sleep activated centrotemporal spikes 4. Has had at least 1 focal motor or generalized seizure Exclusion Criteria: 1. Has abnormal brain MRI 2. Has other unrelated neurological disease 3. Unable to have an MRI/MEG 1. Claustrophobic 2. History of frequent vomiting 3. Permanent metal in body, braces 4. Over MRI weight limit: 350lbs |
Country | Name | City | State |
---|---|---|---|
United States | Athinoula A. Martinos Center Biomedical Imaging | Charlestown | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital | Boston University, National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Spindle-slow oscillation coupling | Cross frequency coupling | 1-5 hours | |
Primary | Spindle Density | Spindle count per minute during non-rapid eye movement (NREM) sleep | 1-5 hours | |
Primary | Memory performance | Percent improvement in memory task performance | 1-5 hours |
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