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Correlation of Serum Level of Perampanel (PER) Level to Cerebrospinal Fluid (CSF) Levels of PER

Epilepsy Clinical Trial

Official title:
Correlation of Serum Level of Perampanel (PER) Level to Cerebrospinal Fluid (CSF) Levels of PER

Clinical Trial Summary

Perampanel is a drug used to treat patients with epilepsy/seizures. This study is designed to determine how much perampanel actually crosses the blood brain barrier into the cerebral spinal fluid when the drug is taken.

Clinical Trial Description

Perampanel is a drug used to treat patients with epilepsy/seizures. This study is designed to determine how much perampanel actually crosses the blood brain barrier into the cerebral spinal fluid when the drug is taken. During a routinely scheduled neurosurgical procedure, one to two mL of cerebral spinal fluid will be obtained from the subarachnoid space of the brain. Five mL of arterial blood will also be drawn from the patients arterial line during their procedure. The blood samples and cerebral spinal fluid samples will be compared to see how much perampanel is in the blood versus the cerebrospinal fluid. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04118829
Study type Interventional
Source Carilion Clinic
Contact Jordan Darden, PhD
Phone 540-981-7942
Email jadarden@carilionclinic.org
Status Recruiting
Phase Phase 4
Start date November 1, 2019
Completion date March 2023
View Details
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