Emergency Medical Services and Epilepsy in Switzerland

Epilepsy Clinical Trial

Official title:

Treatment of Epilepsy in Children and Adults in the Emergency Medical Services of the City of Zurich, Switzerland - Midazolam Versus Diazepam - A Retrospective Analysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03346382
• Other study ID #: OMT 01012015 SRZ
• Status: Completed
• Phase: N/A
• First received: November 2, 2017
• Last updated: November 14, 2017
• Start date: March 1, 2015
• Est. completion date: June 30, 2016

Study information

• Verified date: November 2017
• Source: Balgrist University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Retrospective data analysis, all emergency medical services of the city of Zurich interventions due to epileptic convulsions during June 2013 and December 2014 have been analyzed regarding the type of drug used, its application mode and the application mode based success. Furthermore, children versus adults were compared. Continuous variables were summarized as mean ± standard deviation (SD) and also presented as median [minimum; maximum]. Groups were compared using the independent samples t-test. P-values < 0.05 are considered significant.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 584
• Est. completion date: June 30, 2016
• Est. primary completion date: December 31, 2015
• Gender: All
• Age group: N/A to 99 Years

Eligibility

Inclusion Criteria:

• emergency calls for epileptic seizures received by the emergency medical system of Zurich,Switzerland,

• the use of midazolam or diazepam or no drug used.

Exclusion Criteria:

• the use of any other first line drug to stop seizures than the two mentioned above e.g. thiopental

Related Conditions & MeSH terms

• Emergencies
• Epilepsy

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Theusinger Oliver M.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Which drug (Midazolam versus Diazepam) better stops epileptic seizures in the pre-clinical setting	In this retrospective trial, all Emergency Medical Services of the city of Zurich interventions due to epileptic seizures during June 2013 and December 2014 are analyzed regarding the two drugs (Midazolam or Diazepam) used, its application mode (intravenous, nasal, intramuscular, rectal) and the application mode based success. Data will be collected regarding these aspects in order to determine if one drug is better than the other one, and which application mode is the most efficient.; Furthermore, children versus adults are compared. Continuous variables are summarized as mean ± standard deviation (SD) and also presented as median [minimum; maximum]. Groups are compared using the independent samples t-test. P-values < 0.05 are considered significant.	follow up up to 1 year
Secondary	Does the way of application of the drugs (Midazolam versus Diazepam) used in pre-clinical epileptic seizures influence the outcome	In this retrospective trial, all Emergency Medical Services of the city of Zurich interventions due to epileptic seizures during June 2013 and December 2014 are analyzed regarding the two drugs (Midazolam or Diazepam) used, its application mode (intravenous, nasal, intramuscular, rectal) and the application mode based success. Data will be collected regarding these aspects in order to determine if one drug is better than the other one, and which application mode is the most efficient.; Furthermore, children versus adults are compared. Continuous variables are summarized as mean ± standard deviation (SD) and also presented as median [minimum; maximum]. Groups are compared using the independent samples t-test. P-values < 0.05 are considered significant.	follow up up to 1 year