Epilepsy Clinical Trial
Official title:
Cortical Excitability Changes Induced by Retigabine: a Transcranial Magnetic Stimulation Study
The objective of this study is to characterize the effects of a single-dose of retigabine on cortical excitability in healthy subjects, as quantified by means of TMS.
Epilepsy is a disorder of brain excitability. Antiepileptic drugs (AEDs) modulate this
excitability and transcranial magnetic stimulation (TMS) imposed itself as one of the best
noninvasive methods to study cortical excitability in human subjects.
Based on several recent studies, we hypothesize that measuring TMS parameters in the
patients suffering from epilepsy can rapidly predict the effectiveness of the newly given
AED and, ultimately, guide the optimization of the AED therapy. Characterizing the
neurophysiological properties of innovative AEDs such as retigabine with TMS will allow 1)
to better understand how AEDs modulate, in vivo, cortical excitability in humans in relation
to their mode of action and 2) to establish TMS as a tool for assessing individual
responsiveness to a particular AED treatment and for antiepileptic treatment monitoring.
The effects of most AEDs on cortical excitability have been investigated. The modifications
of the excitability parameters are related to the specific mode of action of each AED. For
the new AED retigabine, at least two modes of action are known: 1) increase in cellular
potassium efflux by changing conformation of the KV7.2-7.3 channels and 2) enhancement of
GABA-A activity.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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